Liu Junjie, Liu Huilin, Zhang Ying, Zheng Yichen, Li Jing, Pan Chao, Jiang Ke, Cheng Jianhong
Wuhan Aier Hankou Eye Hospital, Aier Eye Hospital Affiliated to Wuhan University, No.328,Machang Street, Jianghan District, Wu Han, 320000, China.
Wuhan Aier Eye Hospital, Aier Eye Hospital Affiliated to Wuhan University, No.481, Zhongshan Road, Wuchang District, WuHan, 320000, China.
BMC Ophthalmol. 2025 Aug 27;25(1):487. doi: 10.1186/s12886-025-04311-5.
To observe the clinical effects of Nd: YAG laser vitreolysis in patients with physiological vitreous floaters by A/B ultrasound and infrared fundus photography., and to evaluate the safety of the treatment by ffERG.
Thirty eyes diagnosed with physiological vitreous floaters were enrolled. Examination of BCVA, IOP, SLO, A/B ultrasound, infrared fundus photography and ffERG were performed. The vitreolysis was performed for all patients by the same skilled doctor using an ELLEX YAG laser vitreolysis machine. The IOP was measured half an hour after the operation. After treatment, the patients were followed up at 1 day, 1 week, and 1 month. At follow-up, the same thorough examination as before the operation was performed. ImageJ software was used to measure the size of the vitreous floaters in the infrared fundus photography pictures before and after treatment.
There was no significant difference in BCVA and IOP before and after treatment ( > 0.05). Infrared fundus photography showed that the vitreous floaters were obviously reduced or disappeared after treatment, and the difference was statistically significant ( < 0.01). The latent period and amplitude of the five response waves of ffERG at each timepoint were compared before and after treatment, and there was no significant difference ( > 0.05). Ultra-wide angle SLO showed no severe complications in the vitreous or retina after treatment.
In short-term observations, Nd: YAG laser vitreolysis is safe and effective for the treatment of vitreous floaters and can be promoted clinically.
通过A/B超及红外眼底照相观察Nd:YAG激光玻璃体溶解术治疗生理性玻璃体混浊患者的临床效果，并通过闪光视网膜电图（ffERG）评估治疗安全性。
纳入30例诊断为生理性玻璃体混浊的患眼。进行最佳矫正视力（BCVA）、眼压（IOP）、超广角激光扫描检眼镜（SLO）、A/B超、红外眼底照相及ffERG检查。由同一位技术熟练的医生使用ELLEX YAG激光玻璃体溶解机对所有患者进行玻璃体溶解术。术后半小时测量眼压。治疗后，于1天、1周和1个月对患者进行随访。随访时，进行与术前相同的全面检查。使用ImageJ软件测量治疗前后红外眼底照相图片中玻璃体混浊的大小。
治疗前后BCVA和IOP无显著差异（>0.05）。红外眼底照相显示治疗后玻璃体混浊明显减轻或消失，差异有统计学意义（<0.01）。比较治疗前后各时间点ffERG五个反应波的潜伏期和波幅，无显著差异（>0.05）。超广角SLO显示治疗后玻璃体或视网膜无严重并发症。
短期观察表明，Nd:YAG激光玻璃体溶解术治疗玻璃体混浊安全有效，可在临床推广。
