Lin Tiezhu, Li Tongtong, Zhang Xinmei, Hui Yannian, Moutari Salissou, Pazo Emmanuel Eric, Dai Guangzheng, Shen Lijun
Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
He Eye Specialist Hospital, Shenyang, Liaoning, China.
Ophthalmol Ther. 2022 Feb;11(1):201-214. doi: 10.1007/s40123-021-00422-6. Epub 2021 Nov 15.
To evaluate and compare the efficacy and safety of YAG laser vitreolysis in treating symptomatic vitreous floaters of complete posterior vitreous detachment (PVD) and non-PVD.
In this prospective cohort study, 51 eyes with symptomatic floaters were treated with YAG laser vitreolysis. Participants were divided into complete PVD and non-PVD groups. Objective visual quality measures including the Strehl ratio (SR), internal spherical aberration (SA), internal comatic aberration (CA), internal high-order aberration (HOA), area ratio of modulation transfer function (MTFa) and Vitreous Floaters Symptom Questionnaire (VFSQ-13) scores were used to compare the efficacy of YAG laser vitreolysis treatment between two groups.
The mean age of all patients was 56.80 ± 10.82 years old. In total, 36 of 51 (70.59%; 95% CI 58.10-83.10) patients reported their symptoms as significant or complete improvement after YAG laser vitreolysis treatment. Post-treatment MTFa, internal SA and internal HOA were significantly better compared to baseline (26.19 ± 14.73 vs. 29.19 ± 17.98, p = 0.013; 0.05 ± 0.05 vs. 0.04 ± 0.04, p = 0.031 and 0.23 ± 0.22 vs. 0.16 ± 0.07, p = 0.044; respectively) in all eyes. Twenty-nine of 51 (56.86%) eyes had floaters of non-PVD type. Significant or complete subjective improvements in the PVD group and non-PVD group were 72.73% and 68.97% (p = 0.344), respectively.
Improved subjective and objective visual quality in participants with symptomatic floaters following YAG laser vitreolysis was found in both groups. The efficacy of YAG laser vitreolysis was comparable in floaters of complete PVD and non-PVD types.
评估并比较YAG激光玻璃体溶解术治疗完全性玻璃体后脱离（PVD）和非PVD所致有症状玻璃体混浊的疗效和安全性。
在这项前瞻性队列研究中，51例有症状玻璃体混浊患者接受了YAG激光玻璃体溶解术治疗。参与者被分为完全性PVD组和非PVD组。采用客观视觉质量指标，包括斯特列尔比（SR）、内部球差（SA）、内部慧差（CA）、内部高阶像差（HOA）、调制传递函数面积比（MTFa）和玻璃体混浊症状问卷（VFSQ - 13）评分，比较两组YAG激光玻璃体溶解术治疗的疗效。
所有患者的平均年龄为56.80±10.82岁。51例患者中有36例（70.59%；95%CI 58.10 - 83.10）报告在YAG激光玻璃体溶解术治疗后症状显著改善或完全改善。所有眼治疗后的MTFa、内部SA和内部HOA与基线相比均有显著改善（分别为26.19±14.73 vs. 29.19±17,98，p = 0.013；0.05±0.05 vs. 0.04±0.04，p = 0.031；0.23±0.22 vs. 0.16±0.07，p = 0,044）。51只眼中有29只（56.86%）为非PVD型玻璃体混浊。PVD组和非PVD组主观症状显著改善或完全改善的比例分别为72.73%和68.97%（p = 0.344）。
两组有症状玻璃体混浊患者在接受YAG激光玻璃体溶解术后，主观和客观视觉质量均得到改善。YAG激光玻璃体溶解术在治疗完全性PVD型和非PVD型玻璃体混浊方面疗效相当。
