委内瑞拉疟疾患者的CYP2D6基因型与伯氨喹治疗
CYP2D6 Genotype and Primaquine Treatment in Patients with Malaria, Venezuela.
作者信息
Pacheco César, Hernández-Acosta Adán, Pulido Narviz, Ceballos Yvanna, Saavedra Daniel, Gómez Cruz, Moreno Nancy, Herrera Flor
出版信息
Emerg Infect Dis. 2025 Sep;31(9):1807-1810. doi: 10.3201/eid3109.250316.
PMID:40867022
Abstract
We determined CYP2D64 and CYP2D6 genotypes and metabolizer phenotypes in 96 patients with suspected malaria in Venezuela and found intermediate or poor metabolizer phenotypes in ≈25% of cases. Nine of 44 malaria patients had Plasmodium vivax recurrence. Public health authorities should evaluate the benefits of increasing total doses of primaquine for treatment.
摘要
我们测定了委内瑞拉96例疑似疟疾患者的CYP2D64和CYP2D6基因型及代谢表型，发现约25%的病例存在中间或慢代谢表型。44例疟疾患者中有9例出现间日疟复发。公共卫生当局应评估增加伯氨喹总剂量用于治疗的益处。
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