Romeo Zaira, Macchia Eleonora, Ceolin Chiara, Devita Maria, Morandi Alessandro, Noale Marianna, Maggi Stefania
Neuroscience Institute, National Research Council, 35128 Padua, Italy.
Geriatrics Unit, Department of Medicine (DIMED), University of Padua, 35128 Padua, Italy.
Healthcare (Basel). 2025 Aug 14;13(16):1999. doi: 10.3390/healthcare13161999.
: Multidisciplinary approaches spanning the physical, cognitive, and social domains of geriatric evaluation are essential to promote functional well-being and reduce the aversive consequences of aging. The main objective of the pilot study, "Multidomain Interventions to improve the COgnitive and fUNctional well-being of elderly individuals in residential sTructures" (I-COUNT), is to assess the feasibility of a 6-month multidomain intervention performed on older adults in Long-Term Care Facilities (LTCFs), compared with a group of residents following a traditional care approach. : The intervention will involve two LTCFs in Italy and will include physical exercise and cognitive training, administered and monitored using wearable technologies, a nutritional program based on the Mediterranean diet enriched with selected functional foods, and the administration of the vaccinations recommended in the national vaccination plan. The I-COUNT study will assess the feasibility and acceptability of the defined protocol and provide information to determine the sample size for a definitive study. In relation to the potential health impact of multidomain interventions on older people living in LTCFs, the primary outcome will consider the change in microbiota composition assessed 3 months after the start of interventions, while secondary outcomes will include the evaluation of changes in selected biomarkers, physical performance, psychological health, cognitive functioning, and nutritional status at 6- and 9-month follow-up points. : The I-COUNT study will allow us to assess the feasibility of delivering a multidomain intervention on elderly people. Exploratory findings on potential health effect will support the development of a larger-scale randomized controlled trial. : ClinicalTrials.gov ID NCT06820710.
跨越老年评估的身体、认知和社会领域的多学科方法对于促进功能健康和减少衰老的不良后果至关重要。试点研究“多领域干预以改善居住机构中老年人的认知和功能健康”（I-COUNT）的主要目标是评估对长期护理机构（LTCFs）中的老年人进行为期6个月的多领域干预的可行性，并与采用传统护理方法的一组居民进行比较。：该干预将涉及意大利的两个长期护理机构，包括体育锻炼和认知训练，使用可穿戴技术进行管理和监测，基于富含特定功能性食品的地中海饮食的营养计划，以及国家疫苗接种计划中推荐疫苗的接种。I-COUNT研究将评估既定方案的可行性和可接受性，并提供信息以确定确定性研究的样本量。关于多领域干预对居住在长期护理机构中的老年人的潜在健康影响，主要结果将考虑干预开始3个月后评估的微生物群组成变化，而次要结果将包括在6个月和9个月随访点对选定生物标志物、身体表现、心理健康、认知功能和营养状况变化的评估。：I-COUNT研究将使我们能够评估对老年人进行多领域干预的可行性。关于潜在健康影响的探索性发现将支持开展更大规模的随机对照试验。：ClinicalTrials.gov标识符NCT06820710。
