Zhang Lihong, Kulyar Md F, Niu Tian, Yang Shuai, Chen Wenjing
College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.
College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
Microorganisms. 2024 Aug 10;12(8):1636. doi: 10.3390/microorganisms12081636.
To gain deeper insights into the genomic characteristics of () YLR001 and uncover its probiotic properties, in the current study, a comprehensive analysis of its whole genome was conducted, explicitly exploring the genetic variations associated with different host organisms. The genome of YLR001 consisted of a circular 2,242,943 bp chromosome with a GC content of 38.84%, along with three circular plasmids (24,864, 38, 926, and 132,625 bp). Among the 2183 protein-coding sequences (CDSs), the specific genes associated with genetic adaptation and stress resistance were identified. We predicted the function of COG protein genes and analyzed the KEGG pathways. Comparative genome analysis revealed that the pan-genome contained 5207 gene families, including 475 core gene families and 941 strain-specific genes. Phylogenetic analysis revealed distinct host specificity among 20 strains of , highlighting substantial genetic diversity across different hosts. This study enhanced our comprehension of the genetic diversity of YLR001, demonstrated its potential probiotic characteristics, and established more solid groundwork for future applications.
为了更深入地了解（）YLR001的基因组特征并揭示其益生菌特性，在本研究中，对其全基因组进行了全面分析，明确探索了与不同宿主生物体相关的遗传变异。YLR001的基因组由一个2,242,943 bp的环状染色体组成，GC含量为38.84%，还有三个环状质粒（24,864、38,926和132,625 bp）。在2183个蛋白质编码序列（CDS）中，鉴定出了与遗传适应和抗逆性相关的特定基因。我们预测了COG蛋白基因的功能并分析了KEGG途径。比较基因组分析表明，泛基因组包含5207个基因家族，其中包括475个核心基因家族和941个菌株特异性基因。系统发育分析揭示了20株（）之间明显的宿主特异性，突出了不同宿主之间的大量遗传多样性。本研究增强了我们对YLR001遗传多样性的理解，证明了其潜在的益生菌特性，并为未来应用奠定了更坚实的基础。
