Saxod R, Torch S, Vila A, Laurent A, Stoebner P
J Neurol Sci. 1985 Nov;71(1):49-64. doi: 10.1016/0022-510x(85)90036-x.
The density of myelinated fibres in the superficial peroneal nerve was studied in 41 samples from 24 control human subjects. Photographic montages of the whole nerve fascicle were made from semithin and ultrathin transverse sections and used for a statistical analysis of sampling procedures, range of variations and relations between density and other variables. The results indicate that the spatial distribution of myelinated fibres within a nerve is often non-uniform. Therefore, it was not possible to define a statistically valid sampling system. The study of relations between variables shows the lack of any correlation between density and age and a considerable variation in the density. In contrast, there is a strong positive linear correlation between the surface area of the nerve fascicle and its content of myelinated fibres. That is, the fibre density of a given normal nerve is related to its diameter and can be predicted within a narrow range of error. We propose the term "derived density" for this value, and its application as a tool in the diagnosis of peripheral neuropathies is now being studied.
对24名对照人体受试者的41个样本中的腓浅神经有髓纤维密度进行了研究。从半薄和超薄横切片制作了整个神经束的摄影蒙太奇，并用于对采样程序、变异范围以及密度与其他变量之间的关系进行统计分析。结果表明，神经内有髓纤维的空间分布通常不均匀。因此，不可能定义一个具有统计学有效性的采样系统。变量之间关系的研究表明，密度与年龄之间缺乏任何相关性，且密度存在相当大的变化。相比之下，神经束的表面积与其有髓纤维含量之间存在很强的正线性相关性。也就是说，给定正常神经的纤维密度与其直径相关，并且可以在较窄的误差范围内进行预测。我们为此值提出“衍生密度”这一术语，目前正在研究将其作为诊断周围神经病变的工具的应用。
