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多组学揭示与哮喘相关炎症相关的呼吸道微生物组和磷脂组学的异常表型。

Multi-Omics Reveals Aberrant Phenotypes of Respiratory Microbiome and Phospholipidomics Associated with Asthma-Related Inflammation.

作者信息

Liu Huan, Li Zemin, Zhang Xu, Zhao Jiang-Chao, Chai Jianmin, Chang Chun

机构信息

Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China.

Research Center for Chronic Airway Diseases, Peking University Health Science Center, Beijing 100083, China.

出版信息

Microorganisms. 2025 Jul 28;13(8):1761. doi: 10.3390/microorganisms13081761.

DOI:10.3390/microorganisms13081761
PMID:40871265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12388397/
Abstract

Respiratory microbiota and lipids are closely associated with airway inflammation. This study aimed to analyze the correlations among the respiratory microbiome, the airway glycerophospholipid-sphingolipid profiles, and airway inflammation in patients with asthma. We conducted a cross-sectional study involving 61 patients with asthma and 17 healthy controls. Targeted phospholipidomics was performed on exhaled breath condensate (EBC) samples, and microbial composition was analyzed via the 16S rDNA sequencing of induced sputum. Asthma patients exhibited significant alterations in the EBC lipid profiles, with reduced levels of multiple ceramides (Cer) and glycerophospholipids, including phosphatidylethanolamine (PE) and phosphatidylcholine (PC), compared with healthy controls. These lipids were inversely correlated with the sputum interleukin-4 (IL-4) levels. Microbiome analysis revealed an increased abundance of and in asthma patients, both positively associated with IL-4. Correlation analysis highlighted a potential interaction network involving PA, PE, ceramides, , , , and . Specific alterations in airway microbiota and phospholipid metabolism are associated with asthma-related inflammation, supporting the concept of a microbiota-phospholipid-immune axis and providing potential targets for future mechanistic and therapeutic studies.

摘要

呼吸道微生物群和脂质与气道炎症密切相关。本研究旨在分析哮喘患者呼吸道微生物组、气道甘油磷脂-鞘脂谱和气道炎症之间的相关性。我们进行了一项横断面研究，纳入了61例哮喘患者和17名健康对照。对呼出气冷凝液（EBC）样本进行靶向磷脂组学分析，并通过诱导痰的16S rDNA测序分析微生物组成。与健康对照相比，哮喘患者的EBC脂质谱有显著改变，多种神经酰胺（Cer）和甘油磷脂水平降低，包括磷脂酰乙醇胺（PE）和磷脂酰胆碱（PC）。这些脂质与痰中白细胞介素-4（IL-4）水平呈负相关。微生物组分析显示哮喘患者中[具体微生物名称1]和[具体微生物名称2]丰度增加，两者均与IL-4呈正相关。相关性分析突出了一个潜在的相互作用网络，涉及磷脂酸（PA）、PE、神经酰胺、[具体微生物名称1]、[具体微生物名称2]、[具体物质1]和[具体物质2]。气道微生物群和磷脂代谢的特定改变与哮喘相关炎症有关，支持微生物群-磷脂-免疫轴的概念，并为未来的机制和治疗研究提供了潜在靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d57/12388397/61866016cf3d/microorganisms-13-01761-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d57/12388397/691c4667db52/microorganisms-13-01761-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d57/12388397/65623c3eec29/microorganisms-13-01761-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d57/12388397/9df14113b1a4/microorganisms-13-01761-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d57/12388397/a4f414b3b3f9/microorganisms-13-01761-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d57/12388397/2da62a7cd62e/microorganisms-13-01761-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d57/12388397/cfe944fbd650/microorganisms-13-01761-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d57/12388397/61866016cf3d/microorganisms-13-01761-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d57/12388397/691c4667db52/microorganisms-13-01761-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d57/12388397/65623c3eec29/microorganisms-13-01761-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d57/12388397/9df14113b1a4/microorganisms-13-01761-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d57/12388397/a4f414b3b3f9/microorganisms-13-01761-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d57/12388397/2da62a7cd62e/microorganisms-13-01761-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d57/12388397/cfe944fbd650/microorganisms-13-01761-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d57/12388397/61866016cf3d/microorganisms-13-01761-g007.jpg

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本文引用的文献

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Omics approaches in asthma research: Challenges and opportunities.哮喘研究中的组学方法：挑战与机遇。
Chin Med J Pulm Crit Care Med. 2024 Mar 2;2(1):1-9. doi: 10.1016/j.pccm.2024.02.002. eCollection 2024 Mar.
2
Characterization of the upper respiratory tract microbiota in Chilean asthmatic children reveals compositional, functional, and structural differences.智利哮喘儿童上呼吸道微生物群的特征揭示了其在组成、功能和结构上的差异。
Front Allergy. 2023 Jul 28;4:1223306. doi: 10.3389/falgy.2023.1223306. eCollection 2023.
3
Greengenes2 unifies microbial data in a single reference tree.
Greengenes2 将微生物数据统一在一个单一的参考树中。
Nat Biotechnol. 2024 May;42(5):715-718. doi: 10.1038/s41587-023-01845-1. Epub 2023 Jul 27.
4
Multi-Omics Analysis of Lung Tissue Demonstrates Changes to Lipid Metabolism during Allergic Sensitization in Mice.小鼠肺组织的多组学分析揭示了变应性致敏过程中脂质代谢的变化。
Metabolites. 2023 Mar 9;13(3):406. doi: 10.3390/metabo13030406.
5
Lipidomic Analysis Reveals Differences in Species Driven Largely by Plasmalogens, Glycerophosphoinositols and Certain Sphingolipids.脂质组学分析揭示了物种间的差异，这些差异主要由缩醛磷脂、甘油磷酸肌醇和某些鞘脂驱动。
Metabolites. 2023 Feb 28;13(3):360. doi: 10.3390/metabo13030360.
6
Microbiome and Asthma: Microbial Dysbiosis and the Origins, Phenotypes, Persistence, and Severity of Asthma.微生物组与哮喘：哮喘的起源、表型、持续性和严重程度的微生物失调。
Nutrients. 2023 Jan 17;15(3):486. doi: 10.3390/nu15030486.
7
Gut microbiome lipid metabolism and its impact on host physiology.肠道微生物组的脂质代谢及其对宿主生理学的影响。
Cell Host Microbe. 2023 Feb 8;31(2):173-186. doi: 10.1016/j.chom.2023.01.009.
8
Roles of sirtuins in asthma.沉默信息调节因子 2 相关酶在哮喘中的作用。
Respir Res. 2022 Sep 18;23(1):251. doi: 10.1186/s12931-022-02175-7.
9
What has been learned by cytokine targeting of asthma?哮喘的细胞因子靶向治疗有哪些新认识？
J Allergy Clin Immunol. 2022 Aug;150(2):235-249. doi: 10.1016/j.jaci.2022.06.010.
10
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Gut Microbes. 2022 Jan-Dec;14(1):2096994. doi: 10.1080/19490976.2022.2096994.