Liang Yumeng, Qi Wei, Fu Jiawen, Jia Honglin
State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
Heilongjiang Research Center for Veterinary Biopharmaceutical Technology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
Pathogens. 2025 Aug 1;14(8):763. doi: 10.3390/pathogens14080763.
The apicoplast is a highly specialized organelle in the biosynthesis of essential metabolites in most of the apicomplexan protozoa. This organelle is surrounded by four layers of membranes. However, the molecular mechanisms mediating transmembrane transport are not yet fully understood. In this study, we conducted a phenotypic analysis to investigate the role of a major facilitator superfamily transporter (TgApMFS1) in the survival of the parasite. The results indicated that TgApMFS1 is critical for the survival of in cell culture conditions. Further analysis indicated that these transporters are crucial for the biogenesis of organelles and the metabolic processes of parasite.
顶质体是大多数顶复门原生动物中参与必需代谢物生物合成的高度特化细胞器。该细胞器被四层膜包围。然而，介导跨膜运输的分子机制尚未完全了解。在本研究中，我们进行了表型分析，以研究主要易化子超家族转运蛋白（TgApMFS1）在寄生虫存活中的作用。结果表明，TgApMFS1在细胞培养条件下对寄生虫的存活至关重要。进一步分析表明，这些转运蛋白对细胞器的生物发生和寄生虫的代谢过程至关重要。
