da Cunha José Marcos Telles, Gutfilen-Schlesinger Gabriel, Trope Beatriz Moritz, Lopes Flávia Paiva Proença Lobo, de Souza Sergio Augusto Lopes, Gutfilen Bianca
Department of Internal Medicine, Dermatology Service, Medical School, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-913, Brazil.
Laboratório de Marcação de Células e Moléculas (LMCM), Radiology Department, Medical School, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-913, Brazil.
Pharmaceuticals (Basel). 2025 Aug 12;18(8):1190. doi: 10.3390/ph18081190.
Shedding light on Hidradenitis Suppurativa activity: a pilot study to evaluate the potential of [Tc]Tc-anti-TNF-alpha scintigraphy. : Hidradenitis suppurativa (HS), also known as acne inversa and Verneuil's disease, is a chronic and non-contagious auto-inflammatory disease of pilo-sebaceous units that can lead to severe complications and sequelae. The actual prevalence of HS is unknown due to diagnostic delay and/or misdiagnosis, but it is estimated to affect 0.00033-4.1% of the general population worldwide. Only severe cases are referred for imaging assessment, and the final diagnosis is mostly established on a clinical basis. Here, we present a pilot study aiming to evaluate clinically active inflammatory disease in patients with HS using [Tc]Tc-anti-TNF-alpha scintigraphy. : Four patients (2 male, 2 female) had their HS clinical features measured through the HS-PGA and Hurley Score and compared to [Tc]Tc-anti-TNF-alpha scintigraphy findings. : Scintigraphy with [Tc]Tc-anti-TNF-alpha showed abnormal uptake in clinically active lesions of HS and also detected some clinically unknown potential active lesions, later confirmed by clinical reassessment after the imaging. : Our results suggest that scintigraphy with [Tc]Tc-anti-TNF-alpha may be able to detect increased radiotracer uptake in most clinically identified active lesions in this pilot cohort. While promising, due to the inherent limitations of this pilot study, more studies need to be carried out to arrive at a definitive diagnostic assessment of active inflammatory disease using this method.
一项评估[锝]Tc-抗TNF-α闪烁显像潜力的初步研究 ：化脓性汗腺炎（HS），也称为反向性痤疮和韦尔内伊病，是一种毛囊皮脂腺单位的慢性非传染性自身炎症性疾病，可导致严重并发症和后遗症。由于诊断延迟和/或误诊，HS的实际患病率尚不清楚，但据估计全球普通人群中受其影响的比例为0.00033%-4.1%。只有重症病例才会接受影像学评估，最终诊断大多基于临床。在此，我们开展了一项初步研究，旨在使用[锝]Tc-抗TNF-α闪烁显像评估HS患者的临床活动性炎症性疾病。 ：四名患者（2名男性，2名女性）通过HS-PGA和赫尔利评分对其HS临床特征进行了测量，并与[锝]Tc-抗TNF-α闪烁显像结果进行了比较。 ：[锝]Tc-抗TNF-α闪烁显像显示HS临床活动性病变中有异常摄取，还检测到一些临床未知的潜在活动性病变，成像后经临床重新评估得到证实。 ：我们的结果表明，[锝]Tc-抗TNF-α闪烁显像可能能够在这个初步队列中的大多数临床确定的活动性病变中检测到放射性示踪剂摄取增加。虽然前景乐观，但由于这项初步研究的固有局限性，需要开展更多研究，以便使用这种方法对活动性炎症性疾病进行明确的诊断评估。
