钆基造影剂：有关钆使用的常见问题的最新解答。
Gadolinium-Based Contrast Agents: Updates and Answers to Typical Questions Regarding Gadolinium Use.
机构信息
Department of Cardiology, Texas Heart Institute, Houston, Texas.
Department of Cardiovascular Radiology, Texas Heart Institute, Houston, Texas.
出版信息
Tex Heart Inst J. 2022 May 1;49(3). doi: 10.14503/THIJ-21-7680.
Abstract
Gadolinium-based contrast agents have expanded the diagnostic usefulness and capability of magnetic resonance imaging. Despite their highly favorable safety profile, these agents have been associated with nephrogenic systemic fibrosis in a small number of patients who have advanced kidney disease. Recently, trace amounts of gadolinium deposition in the brain and other organs have been reported after contrast exposure, even in patients with normal renal function. In this review, we provide a brief overview of recent updates and discuss typical clinical situations related to the use of gadolinium-based contrast agents.
摘要
钆基造影剂扩展了磁共振成像的诊断用途和能力。尽管这些造影剂具有非常良好的安全性，但在少数患有晚期肾病的患者中，它们与肾源性系统性纤维化有关。最近，即使在肾功能正常的患者中，也有报道称在造影剂暴露后，大脑和其他器官中会有微量的钆沉积。在这篇综述中，我们提供了最新进展的简要概述，并讨论了与使用钆基造影剂相关的典型临床情况。
相似文献
1
Gadolinium-Based Contrast Agents: Updates and Answers to Typical Questions Regarding Gadolinium Use.钆基造影剂：有关钆使用的常见问题的最新解答。
Tex Heart Inst J. 2022 May 1;49(3). doi: 10.14503/THIJ-21-7680.
2
Recent topics related to nephrogenic systemic fibrosis associated with gadolinium-based contrast agents.与钆基造影剂相关的肾源性系统性纤维化的相关研究进展。
Int J Urol. 2012 Sep;19(9):806-11. doi: 10.1111/j.1442-2042.2012.03042.x. Epub 2012 May 9.
3
[Nephrogenic systemic fibrosis: a severe complication of use to gadolinium in patients with kidney failure].[肾源性系统性纤维化：肾衰竭患者使用钆造影剂的严重并发症]
Rev Assoc Med Bras (1992). 2009 Mar-Apr;55(2):220-5. doi: 10.1590/s0104-42302009000200030.
4
Gadolinium-associated nephrogenic systemic fibrosis.钆相关的肾源性系统性纤维化。
Am Fam Physician. 2009 Oct 1;80(7):711-4.
5
Nephrogenic systemic fibrosis: a concise review for cardiologists.肾源性系统性纤维化：心脏病专家简要综述
Tex Heart Inst J. 2010;37(5):508-15.
6
Nephrogenic systemic fibrosis.肾源性系统性纤维化
Magn Reson Imaging Clin N Am. 2009 Feb;17(1):159-67. doi: 10.1016/j.mric.2009.01.003.
7
Prophylactic Hemodialysis for Protection Against Gadolinium-Induced Nephrogenic Systemic Fibrosis: A Doll's House.预防钆诱导的肾源性系统性纤维化的预防性血液透析：一个玩偶之家。
Adv Chronic Kidney Dis. 2017 May;24(3):133-135. doi: 10.1053/j.ackd.2017.03.007.
8
[Nephrogenic fibrosing dermopathy or nephrogenic systemic fibrosis? What do we know and what do we have to learn?].[肾源性纤维化皮肤病还是肾源性系统性纤维化？我们知道什么以及还需要了解什么？]
Nefrologia. 2009;29(2):109-17. doi: 10.3265/Nefrologia.2009.29.2.4842.en.full.
9
Nephrogenic Systemic Fibrosis in the Setting of Transient Renal Insufficiency.肾源性全身纤维化为短暂性肾功能不全的并发症。
Cutis. 2021 Dec;108(6):342-344. doi: 10.12788/cutis.0410.
10
Application of extracellular gadolinium-based MRI contrast agents and the risk of nephrogenic systemic fibrosis.基于钆的细胞外MRI造影剂的应用与肾源性系统性纤维化风险
Rofo. 2014 Jul;186(7):661-9. doi: 10.1055/s-0033-1356403. Epub 2014 Jan 29.
引用本文的文献
1
Current Status and Future Aspects of Gadolinium Oxide Nanoparticles as Positive Magnetic Resonance Imaging Contrast Agents.氧化钆纳米颗粒作为阳性磁共振成像造影剂的现状与未来展望
Nanomaterials (Basel). 2025 Sep 1;15(17):1340. doi: 10.3390/nano15171340.
2
Clinical utility of segmental native T1 mapping for diagnosis and risk-stratification in cardiac sarcoidosis.节段性心肌T1值测绘在心脏结节病诊断及风险分层中的临床应用价值
Int J Cardiol Heart Vasc. 2025 Aug 29;61:101787. doi: 10.1016/j.ijcha.2025.101787. eCollection 2025 Dec.
3
Shedding Light on Hidradenitis Suppurativa Activity: A Pilot Study to Evaluate the Potential of [Tc]Tc-Anti-TNF-Alpha Scintigraphy.揭开化脓性汗腺炎活动的面纱：一项评估[锝]锝-抗肿瘤坏死因子-α闪烁扫描术潜力的初步研究。
Pharmaceuticals (Basel). 2025 Aug 12;18(8):1190. doi: 10.3390/ph18081190.
4
Simultaneous T, T, and T mapping of the myocardium using cardiac MR fingerprinting with a deep image prior reconstruction.使用具有深度图像先验重建的心脏磁共振指纹技术对心肌进行同步T1、T2和T2*映射。
Magn Reson Med. 2025 Oct;94(4):1500-1513. doi: 10.1002/mrm.30580. Epub 2025 May 23.
5
Deep learning approaches for the detection of scar presence from cine cardiac magnetic resonance adding derived parametric images.用于从cine心脏磁共振成像中检测瘢痕存在并添加派生参数图像的深度学习方法。
Med Biol Eng Comput. 2025 Jan;63(1):59-73. doi: 10.1007/s11517-024-03175-z. Epub 2024 Aug 6.
6
[Magnetic resonance arthrography with physiological saline solution in the diagnosis of temporomandibular joint disc perforation. Case report].[生理盐水磁共振关节造影在颞下颌关节盘穿孔诊断中的应用。病例报告]
Rev Cient Odontol (Lima). 2024 Mar 30;12(1):e190. doi: 10.21142/2523-2754-1201-2024-190. eCollection 2024 Jan-Mar.
7
Development of Ln(III) Derivatives as F Parashift Probes.Ln(III) 衍生物作为 F 型顺磁交换探针的发展。
Inorg Chem. 2024 May 27;63(21):9877-9887. doi: 10.1021/acs.inorgchem.4c00652. Epub 2024 May 15.
8
In Vivo Evaluation of Innovative Gadolinium-Based Contrast Agents Designed for Bioimaging Applications.用于生物成像应用的新型钆基造影剂的体内评估
Polymers (Basel). 2024 Apr 11;16(8):1064. doi: 10.3390/polym16081064.
9
Safe and Informed Use of Gadolinium-Based Contrast Agent in Body Magnetic Resonance Imaging: Where We Were and Where We Are.钆基造影剂在体部磁共振成像中的安全与合理使用：我们的过去与现在
J Clin Med. 2024 Apr 10;13(8):2193. doi: 10.3390/jcm13082193.
10
Tannic acid-mediated synthesis of flower-like mesoporous MnO nanostructures as T-T dual-modal MRI contrast agents and dual-enzyme mimetic agents.鞣酸介导合成花状介孔 MnO 纳米结构作为 T1-T2 双模态 MRI 造影剂和双酶模拟物。
Sci Rep. 2023 Sep 5;13(1):14606. doi: 10.1038/s41598-023-41598-0.
本文引用的文献
1
Use of Intravenous Gadolinium-based Contrast Media in Patients with Kidney Disease: Consensus Statements from the American College of Radiology and the National Kidney Foundation.静脉内钆基造影剂在肾脏病患者中的应用：美国放射学会和美国国家肾脏基金会的共识声明。
Radiology. 2021 Jan;298(1):28-35. doi: 10.1148/radiol.2020202903. Epub 2020 Nov 10.
2
No Cases of Nephrogenic Systemic Fibrosis after Administration of Gadoxetic Acid.未发现钆塞酸葡胺给药后发生肾源性系统纤维化病例。
Radiology. 2020 Dec;297(3):556-562. doi: 10.1148/radiol.2020200788. Epub 2020 Sep 29.
3
Incidence of nephrogenic systemic fibrosis after administration of gadoteric acid in patients on renal replacement treatment.在接受肾脏替代治疗的患者中，使用钆特酸给药后的肾源性系统性纤维化发生率。
Magn Reson Imaging. 2020 Jul;70:1-4. doi: 10.1016/j.mri.2020.02.012. Epub 2020 Feb 26.
4
MRI in pregnant patients with suspected abdominal and pelvic cancer: a practical guide for radiologists.MRI 检查在疑似腹部和盆腔癌症的孕妇中的应用：放射科医师实用指南。
Diagn Interv Radiol. 2020 May;26(3):183-192. doi: 10.5152/dir.2019.19343.
5
Risk of Nephrogenic Systemic Fibrosis in Patients With Stage 4 or 5 Chronic Kidney Disease Receiving a Group II Gadolinium-Based Contrast Agent: A Systematic Review and Meta-analysis.接受 II 类钆基造影剂的 4 或 5 期慢性肾脏病患者发生肾源性系统纤维化的风险：系统评价和荟萃分析。
JAMA Intern Med. 2020 Feb 1;180(2):223-230. doi: 10.1001/jamainternmed.2019.5284.
6
Observational study on the incidence of nephrogenic systemic fibrosis in patients with renal impairment following gadoterate meglumine administration: the NSsaFe study.钆特酸葡甲胺给药后肾功能损害患者肾源性系统性纤维化发生率的观察性研究：NSsaFe研究
J Magn Reson Imaging. 2020 Feb;51(2):607-614. doi: 10.1002/jmri.26851. Epub 2019 Jul 9.
7
A Systematic Review of 639 Patients with Biopsy-confirmed Nephrogenic Systemic Fibrosis.经活检证实的 639 例肾源性系统性纤维化患者的系统评价。
Radiology. 2019 Aug;292(2):376-386. doi: 10.1148/radiol.2019182916. Epub 2019 Jul 2.
8
Updated Clinical Practice Guideline on Use of Gadolinium-Based Contrast Agents in Kidney Disease Issued by the Canadian Association of Radiologists.加拿大放射学家协会发布的更新版《肾脏疾病中钆类造影剂使用的临床实践指南》。
Can Assoc Radiol J. 2019 Aug;70(3):226-232. doi: 10.1016/j.carj.2019.04.001. Epub 2019 Jun 27.
9
Gadolinium Deposition in the Brain: Current Updates.钆在脑内沉积：最新进展。
Korean J Radiol. 2019 Jan;20(1):134-147. doi: 10.3348/kjr.2018.0356. Epub 2018 Dec 27.
10
Gadolinium Deposition in the Brain: A Systematic Review of Existing Guidelines and Policy Statement Issued by the Canadian Association of Radiologists.脑内钆沉积：对加拿大放射学家协会发布的现有指南和政策声明的系统评价。
Can Assoc Radiol J. 2018 Nov;69(4):373-382. doi: 10.1016/j.carj.2018.04.002. Epub 2018 Sep 22.
Zotero 插件