Rodrigues-Jesus Joana, Vilhena Hugo, Canadas-Sousa Ana, Dias-Pereira Patrícia
Department of Pathology and Molecular Immunology, School of Medicine and Biomedical Sciences, ICBAS-UP, University of Porto, 4050-313 Porto, Portugal.
Associated Laboratory for Green Chemistry (LAQV), REQUIMTE, University of Porto, 4050-313 Porto, Portugal.
Vet Sci. 2025 Aug 5;12(8):736. doi: 10.3390/vetsci12080736.
As the body of knowledge on feline mammary tumors (FMTs) continues to grow, their histological classification and grading systems have undergone revisions and updates to better reflect the biological behavior of these tumors. In this review, the historical evolution of these frameworks is traced and later revisited in the context of their prognostic relevance. Numerous studies have investigated clinicopathological prognostic factors in feline mammary carcinomas (FMCs); however, the heterogeneity in assessment methods, inclusion criteria for survival analysis, and the clinical endpoints considered can often complicate direct comparisons across different studies and may contribute to seemingly conflicting results. Furthermore, the small cohort size of many studies limits the robustness and transferability of their findings. This paper provides an updated overview of the epidemiological, clinical, and pathological prognostic factors of these tumors, while also highlighting current challenges, methodological limitations, and areas for future improvement.
随着关于猫乳腺肿瘤（FMTs）的知识体系不断发展，其组织学分类和分级系统已经历修订和更新，以更好地反映这些肿瘤的生物学行为。在本综述中，追溯了这些框架的历史演变，并在其预后相关性的背景下进行了重新审视。众多研究调查了猫乳腺癌（FMCs）的临床病理预后因素；然而，评估方法的异质性、生存分析的纳入标准以及所考虑的临床终点常常使不同研究之间的直接比较变得复杂，并可能导致看似相互矛盾的结果。此外，许多研究的队列规模较小，限制了其研究结果的稳健性和可转移性。本文提供了这些肿瘤的流行病学、临床和病理预后因素的最新概述，同时还强调了当前的挑战、方法学局限性以及未来改进的方向。
