University of Sassari, Sassari, Italy.
University of Naples Federico II, Naples, Italy.
Vet Pathol. 2022 Nov;59(6):894-902. doi: 10.1177/03009858221105060. Epub 2022 Jun 23.
Carcinoma in situ of the breast is a well-known entity in humans. In veterinary medicine, particularly in canine and feline mammary literature, there is no agreement whether the term in situ should be used to indicate a specific carcinoma histotype or the noninvasive status of a carcinoma of any histotype. Moreover, in the most recent histologic classification of mammary tumors published by the Davis-Thompson Foundation, it is suggested to abandon the term carcinoma in situ given the lack of standardized criteria defining this entity, replacing it with epitheliosis or ductal/lobular hyperplasia with severe atypia. This publication presents a critical review of the term in situ in human and veterinary medicine considering the evolution of the term over the years and its heterogeneous use by different authors, including variations in immunohistochemical markers for classification. This review aims to point out the lack of uniformity in the nomenclature and classification issues in veterinary medicine regarding the use of the term in situ, laying the ground for a process of standardization in future publications.
乳腺原位癌是人类中一种众所周知的实体。在兽医医学中，特别是在犬科和猫科乳腺文献中，对于术语“原位”是否应用于指示特定的癌组织类型或任何组织类型的癌的非浸润状态，尚无共识。此外，在戴维斯-汤普森基金会（Davis-Thompson Foundation）最近发布的乳腺肿瘤组织学分类中，鉴于缺乏定义该实体的标准化标准，建议放弃“原位癌”一词，代之以上皮增生或导管/小叶增生伴重度异型性。本文通过回顾该术语在人类和兽医医学中的发展历程及其在不同作者中的不同使用情况，包括在分类方面的免疫组织化学标志物的变化，对原位癌这一术语进行了批判性的评价。本文旨在指出兽医医学中在使用“原位”一词时，命名法和分类问题缺乏统一性，为未来出版物中的标准化过程奠定基础。
