Sun Yawei, Li Quanzhi, Xue Weiqi
Sports Department, Nanjing Agricultural University, Nanjing, China.
Sports Training Academy, Nanjing Institute of Physical Education and Sports, Nanjing, China.
Front Endocrinol (Lausanne). 2025 Aug 12;16:1605253. doi: 10.3389/fendo.2025.1605253. eCollection 2025.
This study aimed to investigate the effects of Tai Chi on fasting blood glucose (FBG), HbA1c, blood lipids, blood pressure, and inflammatory markers in patients with type 2 diabetes mellitus (T2DM) through a meta-analysis.
We systematically searched PubMed, Cochrane Library, CNKI, CBM, WanFang, Web of Science, and Embase databases for randomized controlled trials (RCTs) evaluating Tai Chi interventions in T2DM patients. Statistical analyses were performed using Review Manager 5.4 software with random-effects models.
Compared to the control group, Tai Chi significantly reduced: FBG(SMD= -0.57, 95% CI [-0.92,-0.23], =0.001), HbA1c(MD=-0.73, 95%CI[-0.98, -0.49], <0.00001), TG(SMD=-0.50, 95%CI[-0.91, -0.09], =0.02), LDL-C(SMD=-0.70, 95%CI[-1.26, -0.15], =0.01), hs-CRP(SMD=-0.71, 95%CI[-1.10, -0.31], =0.0005), IL-6(SMD=-2.11, 95%CI[-2.88, -1.34], <0.00001), TNF-α(SMD=-3.25, 95%CI[-3.25, -0.53], =0.006). Subgroup analyses indicated optimal FBG reduction with: The standardized 24-form Tai Chi routine; Interventions ≥12 weeks in duration; Exercise frequency >5 sessions/week; Daily exercise duration ≥60 minutes.
Tai Chi demonstrates clinically meaningful benefits for T2DM management. Future RCTs should explore age-specific (e.g., pediatric vs. geriatric) and sex-stratified responses to inform personalized exercise prescriptions.
本研究旨在通过荟萃分析探讨太极拳对2型糖尿病（T2DM）患者空腹血糖（FBG）、糖化血红蛋白（HbA1c）、血脂、血压及炎症标志物的影响。
我们系统检索了PubMed、Cochrane图书馆、中国知网（CNKI）、中国生物医学文献数据库（CBM）、万方数据库、Web of Science和Embase数据库，以查找评估太极拳干预T2DM患者的随机对照试验（RCT）。使用RevMan 5.4软件采用随机效应模型进行统计分析。
与对照组相比，太极拳显著降低了：空腹血糖（SMD = -0.57，95%CI[-0.92, -0.23]，P = 0.001）、糖化血红蛋白（MD = -0.73，95%CI[-0.98, -0.49]，P < 0.00001）、甘油三酯（SMD = -0.50，95%CI[-0.91, -0.09]，P = 0.02）、低密度脂蛋白胆固醇（SMD = -0.70，95%CI[-1.26, -0.15]，P = 0.01）、超敏C反应蛋白（SMD = -0.71，95%CI[-1.10, -0.31]，P = 0.0005）、白细胞介素-6（SMD = -2.11，95%CI[-2.88, -1.34]，P < 0.00001）、肿瘤坏死因子-α（SMD = -3.25，95%CI[-3.25, -0.53]，P = 0.006）。亚组分析表明，采用标准化24式太极拳套路、干预持续时间≥12周、运动频率>5次/周、每日运动持续时间≥60分钟时，空腹血糖降低效果最佳。
太极拳对T2DM管理具有临床意义上的益处。未来的随机对照试验应探索特定年龄（如儿童与老年人）和性别分层的反应，以制定个性化运动处方。
