Zhu Yan, Liu Yunan
Department of Interventional Intervention, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, People's Republic of China.
Cancer Manag Res. 2025 Aug 22;17:1777-1787. doi: 10.2147/CMAR.S536068. eCollection 2025.
To investigate the efficacy of Medication-Psychological-Nursing-Family-Support (MPNFS) theory-based nursing interventions in lung cancer patients undergoing chemotherapy and their impact on cancer-related fatigue (CRF) and pulmonary function.
A retrospective analysis was performed on clinical data from 92 lung cancer patients receiving chemotherapy at our institution between October 2022 and December 2024. Patients were categorized into a control group (n=46, receiving conventional nursing) and an MPNFS group (n=46, receiving MPNFS-guided nursing plus conventional care). Outcomes were compared using validated scales for CRF (Cancer Fatigue Scale, CFS), negative emotions (Self-Rating Anxiety Scale, SAS; Self-Rating Depression Scale, SDS), quality of life (EORTC QLQ-C30), nutritional status (serum albumin, ALB; total protein, TP), pulmonary function (forced vital capacity, FVC; vital capacity, VC), and complication incidence.
CRF: After 6 weeks, cognitive, emotional, and physical fatigue scores decreased in both groups, with greater reductions in the MPNFS group (P<0.05). Negative emotions: SAS and SDS scores decreased in both groups, with more pronounced improvements in the MPNFS group (P<0.05). Quality of life: Physical, social, emotional, and role functioning scores increased in both groups, with greater gains in the MPNFS group (P<0.05). Nutritional indicators: ALB and TP levels rose in both groups, with more significant increases in the MPNFS group (P<0.05). Pulmonary function: FVC and VC improved in both groups, with superior gains in the MPNFS group (P<0.05). Complications: The MPNFS group exhibited lower incidence rates of nausea/vomiting, myelosuppression, fatigue, and malnutrition (P<0.05).
Incorporating MPNFS theory-based nursing interventions alongside conventional care enhances CRF management, mitigates negative emotions, improves nutritional and pulmonary function, elevates quality of life, and reduces complication risks in lung cancer patients undergoing chemotherapy.
探讨基于药物 - 心理 - 护理 - 家庭支持（MPNFS）理论的护理干预对肺癌化疗患者的疗效及其对癌症相关疲劳（CRF）和肺功能的影响。
对2022年10月至2024年12月在我院接受化疗的92例肺癌患者的临床资料进行回顾性分析。患者分为对照组（n = 46，接受常规护理）和MPNFS组（n = 46，接受MPNFS指导的护理加常规护理）。使用经过验证的量表比较两组患者的CRF（癌症疲劳量表，CFS）、负面情绪（自评焦虑量表，SAS；自评抑郁量表，SDS）、生活质量（欧洲癌症研究与治疗组织生活质量核心问卷，EORTC QLQ - C30）、营养状况（血清白蛋白，ALB；总蛋白，TP）、肺功能（用力肺活量，FVC；肺活量，VC）及并发症发生率。
CRF：6周后，两组患者的认知、情绪和身体疲劳评分均下降，MPNFS组下降更明显（P < 0.05）。负面情绪：两组患者的SAS和SDS评分均下降，MPNFS组改善更显著（P < 0.05）。生活质量：两组患者的身体、社会、情绪和角色功能评分均升高，MPNFS组升高幅度更大（P < 0.05）。营养指标：两组患者的ALB和TP水平均升高，MPNFS组升高更显著（P < 0.05）。肺功能：两组患者的FVC和VC均改善，MPNFS组改善更优（P < 0.05）。并发症：MPNFS组恶心/呕吐、骨髓抑制、疲劳和营养不良的发生率较低（P < 0.05）。
在常规护理的基础上加入基于MPNFS理论的护理干预，可加强CRF管理，减轻负面情绪，改善营养和肺功能，提高生活质量，并降低肺癌化疗患者的并发症风险。
