Plaza-Florido Abel, Alejo Lidia B, Pérez-Prieto Inmaculada, Carrera-Bastos Pedro, Muñoz María Rosado, Aldazabal Itziar Pagola, Barranco-Gil David, Santos-Lozano Alejandro, Rodríguez-Romo Gabriel, Yanguas-Casás Natalia, Radom-Aizik Shlomit, Lucia Alejandro, Fiuza-Luces Carmen
Research Center for Exercise Medicine and Sleep/Pediatric Exercise and Genomics Research Center, Department of Pediatrics, School of Medicine, University of California Irvine, Irvine, California, USA.
Faculty of Medicine, Health and Sports. Department of Sport Sciences, Universidad Europea de Madrid, Madrid, Spain.
Aging Cell. 2025 Sep;24(9):e70152. doi: 10.1111/acel.70152. Epub 2025 Jul 15.
Centenarians exhibit remarkable disease resilience despite chronic low-grade inflammation. We investigated the inflammation-related proteome response to acute exercise in seven centenarians (100-104 years). Exercise downregulated 52 proteins (e.g., TNF, IL10, IL1RN, CCL family members) involved in immune cell trafficking, apoptosis, and cytokine regulation. Even at the extreme end of the lifespan, humans retain molecular responsiveness to exercise, with modulation of inflammation-related pathways.
尽管存在慢性低度炎症，但百岁老人表现出显著的疾病抵抗力。我们研究了7名百岁老人（100 - 104岁）对急性运动的炎症相关蛋白质组反应。运动下调了52种参与免疫细胞运输、细胞凋亡和细胞因子调节的蛋白质（如肿瘤坏死因子、白细胞介素10、白细胞介素1受体拮抗剂、趋化因子家族成员）。即使在寿命的极端阶段，人类对运动仍保持分子反应性，炎症相关通路会受到调节。
