Quan Chuqi, Shao Weilin, Yang Yihao, Yao Qian, Yang Zuozhang, Yao Zhihong
Cancer Research Institute of Yunnan Province, Peking University Cancer Hospital Yunnan,Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Bone and Soft Tissue Tumors Research Centre of Yunnan Province, Department of Orthopaedics, Peking University Cancer Hospital Yunnan,Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Cell Death Discov. 2025 Aug 28;11(1):412. doi: 10.1038/s41420-025-02656-w.
The natriuretic peptide receptor (NPR) family (NPRA, NPRB, NPRC) regulates diverse physiological and pathological processes. Mounting evidence implicates NPRs as key regulators of oncogenesis, metastasis, and therapy resistance in multiple cancers. This review integrates current understanding of the distinct mechanisms by which NPR members contribute to cancer development and progression, explores their molecular underpinnings, and discusses translational potential and future directions. A central focus is the context-dependent functional duality of NPR signaling, where specific subtypes act as either oncogenic drivers or tumor suppressors depending on the malignancy.
利钠肽受体（NPR）家族（NPRA、NPRB、NPRC）调节多种生理和病理过程。越来越多的证据表明，NPRs是多种癌症发生、转移和治疗耐药性的关键调节因子。本综述整合了目前对NPR成员促进癌症发展和进展的不同机制的理解，探讨了其分子基础，并讨论了转化潜力和未来方向。一个核心重点是NPR信号的上下文依赖性功能二元性，其中特定亚型根据恶性程度充当致癌驱动因子或肿瘤抑制因子。
