Thomé Patrick, von Recum Jan, Grützner Paul Alfred, Reiter Gregor
Klinik für Unfallchirurgie und Orthopädie, BG Klinik Ludwigshafen, Ludwig-Guttmann-Str. 13, 67071, Ludwigshafen am Rhein, Deutschland.
Unfallchirurgie (Heidelb). 2025 Aug 28. doi: 10.1007/s00113-025-01607-5.
Bone defects in the limbs may result from trauma, debridement during osteitis or pseudarthrosis resection or tumors [1]. Treating bone defects of the femur and tibia poses a substantial challenge in trauma surgery and orthopedics. Interdisciplinary orthoplastic treatment combined with soft tissue reconstruction is often necessary to preserve the extremity and its function. In addition to shortening surgery, various procedures are available for biological reconstruction, including autogenous and allogeneic bone transplantation, the use of osteoconductive bone substitutes, the induced membrane technique also known as the Masquelet technique, distraction osteogenesis and vascularized fibula transfer. Alternatively, megaprostheses can be used as metallic bone substitutes, especially for metaphyseal bone defects of the femur or proximal tibia [1].Bone defects up to 3 cm in size can usually be successfully treated with shortening or primary cancellous bone grafting; however, leg length difference is known to result in functional limitations [2]. The two-stage Masquelet technique can successfully be used to treat not only small and medium-sized defects but also larger defects through modification [2, 3]. Although the Masquelet technique can be used for larger defects, more complex surgical procedures are often employed in such cases. Callus distraction with segment transport is the most common procedure. In addition to external procedures with monorail or ring fixators, internal lengthening procedures with a transporting nail or plate-assisted bone segment transport (PABST) are now available as well [2].
肢体骨缺损可能由创伤、骨髓炎清创或假关节切除术中的清创或肿瘤引起[1]。治疗股骨和胫骨的骨缺损在创伤外科和骨科领域是一项重大挑战。通常需要跨学科的整形治疗并结合软组织重建来保留肢体及其功能。除了缩短手术外,还有多种生物重建方法,包括自体和异体骨移植、使用骨传导性骨替代物、诱导膜技术(也称为Masquelet技术)、牵张成骨和带血管腓骨转移。另外,可使用大型假体作为金属骨替代物,特别是用于股骨或胫骨近端的干骺端骨缺损[1]。
通常,3厘米以内的骨缺损可通过缩短或一期松质骨移植成功治疗;然而,已知腿长差异会导致功能受限[2]。两阶段Masquelet技术不仅可成功用于治疗中小尺寸的骨缺损,还可通过改良用于治疗更大的骨缺损[2, 3]。尽管Masquelet技术可用于更大的骨缺损,但在这种情况下通常需要采用更复杂的手术方法。骨痂牵张结合节段性骨搬运是最常见的方法。除了使用单轨或环形固定器的外部手术方法外,现在也有使用带锁髓内钉或钢板辅助骨段搬运(PABST)的内部延长手术方法[2]。