Fainstein V, Musher D M
Infect Immun. 1979 Oct;26(1):178-82. doi: 10.1128/iai.26.1.178-182.1979.
Selective adherence to host mucosal surfaces is probably a requirement for colonization and infection by bacteria. Since pharyngeal colonization may be an important determinant in the pathogenesis of pneumonia, we studied the adherence of 10 different bacteria to pharyngeal cells obtained from nonsmokers, smokers, and chronic bronchitics. Various patterns of adherence among the different groups of subjects were found. Young healthy smokers had increased adherence of Streptococcus pneumoniae type I and, to a lesser extent, S. pneumoniae type III and Staphylococcus aureus when compared with nonsmokers. Middle-aged smokers with a long history of chronic bronchitis had significantly increased adherence only of untypable Haemophilus influenzae when compared with age-matched nonsmokers. The acquisition of pneumococcal pneumonia by smokers and the role of nontypable Haemophilus species in chronic bronchitis may be determined, in part, by bacterial adherence to pharyngeal cells.
细菌对宿主黏膜表面的选择性黏附可能是其定植和感染的必要条件。由于咽部定植可能是肺炎发病机制中的一个重要决定因素，我们研究了10种不同细菌对非吸烟者、吸烟者和慢性支气管炎患者咽部细胞的黏附情况。在不同组别的受试者中发现了各种黏附模式。与非吸烟者相比，年轻健康吸烟者的Ⅰ型肺炎链球菌黏附增加，Ⅲ型肺炎链球菌和金黄色葡萄球菌的黏附在较小程度上增加。与年龄匹配的非吸烟者相比，有长期慢性支气管炎病史的中年吸烟者仅不可分型流感嗜血杆菌的黏附显著增加。吸烟者患肺炎球菌肺炎以及不可分型嗜血杆菌属在慢性支气管炎中的作用可能部分由细菌对咽部细胞的黏附决定。
