Theopold H M
Laryngol Rhinol Otol (Stuttg). 1985 Dec;64(12):609-13.
In an open study 30 patients with the symptom of tinnitus were treated for 12 weeks with nimodipin (Bay e 9736) 3 X 30 mg/die. 12 patients showed sudden deafness with a history of one day up to more than 20 years. In six cases we observed complete remission, in two cases remission up to 70-80%, in two cases slight improvement. Four patients showed no side reaction to the treatment of nimodipin. Ten patients suffered from so-called degenerative inner ear deafness. 3 (n = 10) showed complete remission, one nearly 90% improvement, another patient showed 60% improvement, one slight improvement, in 4 patients tinnitus persisted. Vertigo-Morbus Menière: 4 out of 30 patients were included with the diagnosis of Morbus Menière with tinnitus. 3 (n = 4) showed complete remission of tinnitus, normal hearing level and no more symptoms of vertigo after 12 or less weeks of treatment with nimodipin. In one case with an history over more than 20 years only the vertigo could be cured. Traumatic inner ear deafness is not apt to be treated with an agent such as nimodipin.
在一项开放性研究中，30名有耳鸣症状的患者接受了尼莫地平（拜耳e 9736）治疗，剂量为每日3次，每次30毫克，为期12周。12名患者患有突发性耳聋，病史从1天至20多年不等。6例患者完全缓解，2例缓解达70%-80%，2例稍有改善。4名患者在尼莫地平治疗过程中未出现副作用。10名患者患有所谓的内耳退行性耳聋，其中3例（n = 10）完全缓解，1例改善近90%，另1例改善60%，1例稍有改善，4例患者耳鸣持续存在。梅尼埃病：30名患者中有4名被诊断为梅尼埃病伴耳鸣。在用尼莫地平治疗12周或更短时间后，其中3例（n = 4）耳鸣完全缓解，听力水平恢复正常，眩晕症状消失。在1例病史超过20年的患者中，仅眩晕症状得以治愈。外伤性内耳耳聋不易用尼莫地平这样的药物治疗。
