Chatterjee Abhishek, De Joydeep, Martin Béatrice, Chélot Elisabeth, Zhong Ping, Rouyer François
Institut des Neurosciences Paris-Saclay, Université Paris-Saclay, CNRS, 91400 Saclay, France.
Institute of Ecology and Environmental Sciences of Paris (iEES-Paris), INRAE, Sorbonne University, CNRS, IRD, UPEC, Université Paris Cité, 78026 Versailles, France.
Sci Adv. 2025 Aug 29;11(35):eadt7168. doi: 10.1126/sciadv.adt7168.
The brain contains distinct circadian oscillators responsible for generating the morning and evening bouts of locomotor activity in light-dark cycles. We lack a mechanistic understanding of how environmental changes reshape the resulting bimodal rest-activity pattern. Here, we uncover a seasonal switch mechanism that remodels the evening bout of activity. Under temperate summer-like conditions, levels of the pigment-dispersing factor (PDF) neuropeptide diminish, triggering a cascade. Lowered PDF receptor (PDFR) signaling disinhibits glycogen synthase kinase 3/SHAGGY to advance the evening output, and in parallel, weakens the siesta-promoting DN1p-SIF axis to expand the evening peak. Under these conditions, DN1p takes over the evening pacemaker role by exerting control over the dorsal lateral oscillator neurons. Our findings elucidate how environment-induced changes in PDFR signaling tip the balanced output of the clock network, aligning daily rhythms with seasonal time. Neuropeptide-driven parallel adjustment of clock circuitry and clock protein functioning likely represents a conserved strategy, enabling animals to adapt their daily behavior to seasonal changes.
大脑包含不同的昼夜节律振荡器，负责在明暗周期中产生早晚的运动活动。我们对环境变化如何重塑由此产生的双峰休息-活动模式缺乏机制上的理解。在这里，我们发现了一种季节性转换机制，该机制重塑了夜间的活动。在类似温带夏季的条件下，色素分散因子（PDF）神经肽的水平降低，引发了一系列反应。降低的PDF受体（PDFR）信号解除了对糖原合酶激酶3/蓬乱蛋白的抑制，从而提前了夜间输出，同时，削弱了促进午睡的DN1p-SIF轴，以扩大夜间峰值。在这些条件下，DN1p通过对背外侧振荡器神经元的控制，接管了夜间起搏器的角色。我们的研究结果阐明了环境诱导的PDFR信号变化如何打破时钟网络的平衡输出，使日常节律与季节时间同步。神经肽驱动的时钟电路和时钟蛋白功能的平行调节可能代表了一种保守策略，使动物能够使其日常行为适应季节变化。
