• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

昼夜节律可塑性通过神经肽基因的调控变化而进化。

Circadian plasticity evolves through regulatory changes in a neuropeptide gene.

机构信息

Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.

Department of Biology, Hofstra University, Hempstead, NY, USA.

出版信息

Nature. 2024 Nov;635(8040):951-959. doi: 10.1038/s41586-024-08056-x. Epub 2024 Oct 16.

DOI:10.1038/s41586-024-08056-x
PMID:39415010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11602725/
Abstract

Many organisms, including cosmopolitan drosophilids, show circadian plasticity, varying their activity with changing dawn-dusk intervals. How this behaviour evolves is unclear. Here we compare Drosophila melanogaster with Drosophila sechellia, an equatorial, ecological specialist that experiences minimal photoperiod variation, to investigate the mechanistic basis of circadian plasticity evolution. D. sechellia has lost the ability to delay its evening activity peak time under long photoperiods. Screening of circadian mutants in D. melanogaster/D. sechellia hybrids identifies a contribution of the neuropeptide pigment-dispersing factor (Pdf) to this loss. Pdf exhibits species-specific temporal expression, due in part to cis-regulatory divergence. RNA interference and rescue experiments in D. melanogaster using species-specific Pdf regulatory sequences demonstrate that modulation of this neuropeptide's expression affects the degree of behavioural plasticity. The Pdf regulatory region exhibits signals of selection in D. sechellia and across populations of D. melanogaster from different latitudes. We provide evidence that plasticity confers a selective advantage for D. melanogaster at elevated latitude, whereas D. sechellia probably suffers fitness costs through reduced copulation success outside its range. Our findings highlight this neuropeptide gene as a hotspot locus for circadian plasticity evolution that might have contributed to both D. melanogaster's global distribution and D. sechellia's specialization.

摘要

许多生物，包括世界性的果蝇，表现出生物钟的可塑性，随着昼夜时长的变化而改变它们的活动。这种行为是如何进化的尚不清楚。在这里，我们比较了黑腹果蝇和塞舌尔果蝇，塞舌尔果蝇是一种赤道地区的生态专化种，经历的光周期变化最小，以研究生物钟可塑性进化的机制基础。塞舌尔果蝇在长光照条件下丧失了延迟傍晚活动高峰时间的能力。在黑腹果蝇/塞舌尔果蝇杂种中筛选生物钟突变体，发现神经肽色素分散因子（Pdf）对此缺失有贡献。Pdf 表现出物种特异性的时间表达，部分原因是顺式调控区的分化。使用物种特异性的 Pdf 调控序列在黑腹果蝇中进行 RNA 干扰和挽救实验表明，这种神经肽的表达调控影响行为可塑性的程度。Pdf 调控区在塞舌尔果蝇和来自不同纬度的黑腹果蝇种群中都表现出选择信号。我们提供的证据表明，可塑性赋予了黑腹果蝇在高纬度地区的选择性优势，而塞舌尔果蝇在其范围之外的交配成功率降低，可能会遭受适应性代价。我们的研究结果强调了这个神经肽基因是生物钟可塑性进化的热点基因，可能为黑腹果蝇的全球分布和塞舌尔果蝇的专化做出了贡献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/2e1269e5f9b8/41586_2024_8056_Fig14_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/30c4ec1cea94/41586_2024_8056_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/6b38693f2b12/41586_2024_8056_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/d432a7c9a560/41586_2024_8056_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/f10edac1abe5/41586_2024_8056_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/53401d8166a0/41586_2024_8056_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/b54997dbc3f9/41586_2024_8056_Fig6_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/3d3716481ce4/41586_2024_8056_Fig7_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/21ac50d0582a/41586_2024_8056_Fig8_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/c360b61707d6/41586_2024_8056_Fig9_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/1d86f2ba189c/41586_2024_8056_Fig10_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/da6405da62e8/41586_2024_8056_Fig11_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/6310be9b71b1/41586_2024_8056_Fig12_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/35c57e829201/41586_2024_8056_Fig13_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/2e1269e5f9b8/41586_2024_8056_Fig14_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/30c4ec1cea94/41586_2024_8056_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/6b38693f2b12/41586_2024_8056_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/d432a7c9a560/41586_2024_8056_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/f10edac1abe5/41586_2024_8056_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/53401d8166a0/41586_2024_8056_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/b54997dbc3f9/41586_2024_8056_Fig6_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/3d3716481ce4/41586_2024_8056_Fig7_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/21ac50d0582a/41586_2024_8056_Fig8_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/c360b61707d6/41586_2024_8056_Fig9_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/1d86f2ba189c/41586_2024_8056_Fig10_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/da6405da62e8/41586_2024_8056_Fig11_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/6310be9b71b1/41586_2024_8056_Fig12_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/35c57e829201/41586_2024_8056_Fig13_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f09c/11602725/2e1269e5f9b8/41586_2024_8056_Fig14_ESM.jpg

相似文献

1
Circadian plasticity evolves through regulatory changes in a neuropeptide gene.昼夜节律可塑性通过神经肽基因的调控变化而进化。
Nature. 2024 Nov;635(8040):951-959. doi: 10.1038/s41586-024-08056-x. Epub 2024 Oct 16.
2
Comparative analysis of Pdf-mediated circadian behaviors between Drosophila melanogaster and D. virilis.黑腹果蝇和粗壮果蝇之间Pdf介导的昼夜节律行为的比较分析。
Genetics. 2009 Mar;181(3):965-75. doi: 10.1534/genetics.108.099069. Epub 2009 Jan 19.
3
Closely Related Fruit Fly Species Living at Different Latitudes Diverge in Their Circadian Clock Anatomy and Rhythmic Behavior.生活在不同纬度的密切相关的果蝇物种在其生物钟解剖结构和节律行为上存在差异。
J Biol Rhythms. 2018 Dec;33(6):602-613. doi: 10.1177/0748730418798096. Epub 2018 Sep 11.
4
DN1(p) circadian neurons coordinate acute light and PDF inputs to produce robust daily behavior in Drosophila.DN1(p) 节律神经元协调急性光照和 PDF 输入，以在果蝇中产生稳健的每日行为。
Curr Biol. 2010 Apr 13;20(7):591-9. doi: 10.1016/j.cub.2010.02.056. Epub 2010 Apr 1.
5
Adaptation of Circadian Neuronal Network to Photoperiod in High-Latitude European Drosophilids.高纬欧洲果蝇昼夜神经元网络对光周期的适应
Curr Biol. 2017 Mar 20;27(6):833-839. doi: 10.1016/j.cub.2017.01.036. Epub 2017 Mar 2.
6
RNA-interference knockdown of Drosophila pigment dispersing factor in neuronal subsets: the anatomical basis of a neuropeptide's circadian functions.RNA 干扰敲低果蝇神经元亚群中的色素分散因子：神经肽的昼夜节律功能的解剖学基础。
PLoS One. 2009 Dec 14;4(12):e8298. doi: 10.1371/journal.pone.0008298.
7
Genetic changes accompanying the evolution of host specialization in Drosophila sechellia.伴随黑腹果蝇塞舌尔种宿主专一化进化的基因变化。
Genetics. 2009 Feb;181(2):721-36. doi: 10.1534/genetics.108.093419. Epub 2008 Nov 24.
8
The neuropeptide PDF acts directly on evening pacemaker neurons to regulate multiple features of circadian behavior.神经肽PDF直接作用于夜间起搏神经元，以调节昼夜节律行为的多个特征。
PLoS Biol. 2009 Jul;7(7):e1000154. doi: 10.1371/journal.pbio.1000154. Epub 2009 Jul 21.
9
Life at High Latitudes Does Not Require Circadian Behavioral Rhythmicity under Constant Darkness.高纬度环境下的生活在持续黑暗下并不需要昼夜节律行为。
Curr Biol. 2019 Nov 18;29(22):3928-3936.e3. doi: 10.1016/j.cub.2019.09.032. Epub 2019 Oct 31.
10
Characterization of clock-related proteins and neuropeptides in Drosophila littoralis and their putative role in diapause.描述果蝇中与生物钟相关的蛋白质和神经肽及其在滞育中的可能作用。
J Comp Neurol. 2023 Oct;531(15):1525-1549. doi: 10.1002/cne.25522. Epub 2023 Jul 26.

引用本文的文献

1
Neuropeptide dynamics coordinate layered plasticity mechanisms adapting circadian behavior to changing environment.神经肽动力学协调分层可塑性机制，使昼夜节律行为适应不断变化的环境。
Sci Adv. 2025 Aug 29;11(35):eadt7168. doi: 10.1126/sciadv.adt7168.
2
Insect circadian plasticity as a proposed target for the expression of parasite extended phenotypes.昆虫昼夜节律可塑性作为寄生虫扩展表型表达的一个潜在靶点。
NPJ Biol Timing Sleep. 2025;2(1):29. doi: 10.1038/s44323-025-00046-0. Epub 2025 Aug 1.
3
Temperature-dependent modulation of light-induced circadian responses in Drosophila melanogaster.

本文引用的文献

1
Unveiling Subtle Geographical Clines: Phenotypic Effects and Dynamics of Circadian Clock Gene Polymorphisms.揭示细微的地理渐变群：昼夜节律钟基因多态性的表型效应及动态变化
Biology (Basel). 2023 Jun 14;12(6):858. doi: 10.3390/biology12060858.
2
Streamlined single-molecule RNA-FISH of core clock mRNAs in clock neurons in whole mount brains.整装脑钟神经元中核心生物钟mRNA的简化单分子RNA荧光原位杂交技术。
Front Physiol. 2022 Nov 9;13:1051544. doi: 10.3389/fphys.2022.1051544. eCollection 2022.
3
RS-FISH: precise, interactive, fast, and scalable FISH spot detection.
温度依赖性对黑腹果蝇光诱导昼夜节律反应的调节
EMBO J. 2025 Jun 30. doi: 10.1038/s44318-025-00499-w.
4
Comparative single-cell transcriptomic atlases of drosophilid brains suggest glial evolution during ecological adaptation.果蝇大脑的比较单细胞转录组图谱表明生态适应过程中的神经胶质进化。
PLoS Biol. 2025 Apr 29;23(4):e3003120. doi: 10.1371/journal.pbio.3003120. eCollection 2025 Apr.
5
Mapping and decoding neuropeptide signaling networks in nervous system function.绘制和解析神经系统功能中的神经肽信号网络
Curr Opin Neurobiol. 2025 Jun;92:103027. doi: 10.1016/j.conb.2025.103027. Epub 2025 Apr 21.
6
Correlation between circadian and photoperiodic latitudinal clines in .昼夜节律与光周期纬度梯度之间的相关性 。（原文似乎不完整）
Open Biol. 2025 Mar;15(3):240403. doi: 10.1098/rsob.240403. Epub 2025 Mar 5.
RS-FISH：精确、交互、快速且可扩展的 FISH 斑点检测。
Nat Methods. 2022 Dec;19(12):1563-1567. doi: 10.1038/s41592-022-01669-y. Epub 2022 Nov 17.
4
A natural timeless polymorphism allowing circadian clock synchronization in "white nights".一种自然的永恒多态性，允许“白夜”中的生物钟同步。
Nat Commun. 2022 Mar 31;13(1):1724. doi: 10.1038/s41467-022-29293-6.
5
Adaptation of to Long Photoperiods of High-Latitude Summers Is Facilitated by the Allele.等位基因促进了向高纬夏季长光照期的适应。
J Biol Rhythms. 2022 Apr;37(2):185-201. doi: 10.1177/07487304221082448. Epub 2022 Mar 18.
6
Using Flies to Understand Social Networks.利用苍蝇了解社交网络。
Front Neural Circuits. 2021 Dec 3;15:755093. doi: 10.3389/fncir.2021.755093. eCollection 2021.
7
: A Genetic Model for Behavioral Evolution and Neuroecology.行为进化与神经生态学的遗传模型
Annu Rev Genet. 2021 Nov 23;55:527-554. doi: 10.1146/annurev-genet-071719-020719. Epub 2021 Sep 16.
8
The Neuropeptide PDF Is Crucial for Delaying the Phase of Evening Neurons Under Long Zeitgeber Periods.神经肽 PDF 对于在长光照周期下延缓夜间神经元的相位至关重要。
J Biol Rhythms. 2021 Oct;36(5):442-460. doi: 10.1177/07487304211032336. Epub 2021 Aug 24.
9
Clock genes and environmental cues coordinate pheromone synthesis, swarming, and mating.生物钟基因和环境线索协调信息素合成、群集和交配。
Science. 2021 Jan 22;371(6527):411-415. doi: 10.1126/science.abd4359.
10
Natural history of social and sexual behavior in fruit flies.果蝇社会和性行为的自然史。
Sci Rep. 2020 Dec 14;10(1):21932. doi: 10.1038/s41598-020-79075-7.