Gansevoort Merel, van de Waarsenburg Matthijs, Boltje Thomas J, Rutjes Floris P J T, van Kuppevelt Toin H, Daamen Willeke F
Department of Medical BioSciences, Research Institute for Medical Innovation, Radboud University Medical Center Geert Grooteplein Zuid 10 6525 GA Nijmegen The Netherlands
Department of Synthetic Organic Chemistry, Institute for Molecules and Materials, Radboud University Heyendaalseweg 135 6525 AJ Nijmegen The Netherlands
RSC Chem Biol. 2025 Jul 28. doi: 10.1039/d5cb00065c.
Achieving skin regeneration following destruction of the epidermis and dermis ( full-thickness wounds) has remained an unachieved goal. The wound healing response is complex and consists of multiple overlapping phases which are tightly choreographed by the ebb and flow of effector molecules. Mimicking this spatiotemporal aspect in pro-regenerative biomaterials may enhance their efficacy and eventually lead to skin regeneration. However, robust spatiotemporal signalling has remained difficult to achieve. The field of bioorthogonal click and click-to-release chemistry may be key to creating spatiotemporal signalling biomaterials. The ability to safely and effectively conjugate or release molecules in complex biological environments has transformed many areas of research. In this review, we aim to highlight the complex nature of wound healing and address how click and click-to-release chemistry approaches could contribute to the development of biomaterials with spatiotemporal control over effector molecules.
在表皮和真皮遭到破坏（全层伤口）后实现皮肤再生，这一目标至今仍未达成。伤口愈合反应十分复杂，由多个相互重叠的阶段组成，这些阶段由效应分子的起伏变化精确编排。在促进再生的生物材料中模拟这种时空特性，可能会提高其功效，并最终实现皮肤再生。然而，强大的时空信号传导一直难以实现。生物正交点击化学和点击释放化学领域可能是创建时空信号传导生物材料的关键。在复杂生物环境中安全有效地结合或释放分子的能力已经改变了许多研究领域。在这篇综述中，我们旨在强调伤口愈合的复杂本质，并探讨点击化学和点击释放化学方法如何有助于开发对效应分子具有时空控制能力的生物材料。
