Zhang Lixin, Gurkan Umut A, Qua Kelli, Swiatkowski Shannon, Hemphill Sheree, Pelfrey Clara M
Clinical and Translational Science Collaborative of Northern Ohio, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
Department of Mechanical and Aerospace Engineering, Case School of Engineering, Case Western Reserve University, Cleveland, OH, United States.
Front Public Health. 2025 Aug 13;13:1560751. doi: 10.3389/fpubh.2025.1560751. eCollection 2025.
The Clinical and Translational Science Award (CTSA) program, funded by the National Center for Advancing Translational Sciences (NCATS), aims to accelerate the translation of research into public health impacts. However, measuring the societal impact of translational research poses challenges due to extended timelines for implementation. This study uses the Translational Science Benefits Model (TSBM) to evaluate the societal impact of CTSA-supported research at the Clinical and Translational Science Collaborative (CTSC) of Northern Ohio at Case Western Reserve University (CWRU). Using the TSBM, we asked how investigators have used the CTSC to demonstrate translational science impacts in public health practice both domestically and internationally. Using a mixed methods approach, this study analyzed TSBM-based survey data from CTSC-supported KL2 Scholars and Pilot Program awardees, along with key publications and interviews, to document societal benefits across four TSBM domains: Clinical & Medical, Community & Public Health, Economic, and Policy & Legislative. Findings demonstrate that CTSC-supported research improved public health by enhancing healthcare access, improving health outcomes, informing policy, and generating economic benefits. These impacts span local, national, and global contexts. By applying a mixed methods approach, we demonstrate the value of using the TSBM not just as an evaluative framework, but as a strategic tool for capturing the real-world significance of translational science. This approach strengthens the ability of CTSA hubs to highlight the broader public value of their work, reinforcing the CTSA program's mission to transform scientific discoveries into lasting health and societal benefits.
由美国国立转化医学推进中心（NCATS）资助的临床与转化科学奖（CTSA）项目旨在加速将研究成果转化为对公共卫生的影响。然而，由于实施时间线较长，衡量转化研究的社会影响面临挑战。本研究使用转化科学效益模型（TSBM）来评估凯斯西储大学（CWRU）北俄亥俄临床与转化科学协作中心（CTSC）中CTSA支持的研究的社会影响。使用TSBM，我们询问了研究人员如何利用CTSC在国内和国际公共卫生实践中展示转化科学的影响。本研究采用混合方法，分析了来自CTSC支持的KL2学者和试点项目获奖者基于TSBM的调查数据，以及关键出版物和访谈，以记录TSBM四个领域的社会效益：临床与医学、社区与公共卫生、经济以及政策与立法。研究结果表明，CTSC支持的研究通过增加医疗服务可及性、改善健康结果、为政策提供信息以及产生经济效益，改善了公共卫生。这些影响涵盖地方、国家和全球范围。通过应用混合方法，我们证明了使用TSBM的价值，它不仅是一个评估框架，而且是一个捕捉转化科学现实意义的战略工具。这种方法增强了CTSA中心突出其工作更广泛公共价值的能力，强化了CTSA项目将科学发现转化为持久健康和社会效益的使命。
