环孢素治疗皮质类固醇抵抗的自身免疫性慢性活动性肝炎。
Cyclosporin in the treatment of corticosteroid resistant autoimmune chronic active hepatitis.
作者信息
Jackson L D, Song E
机构信息
Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa.
出版信息
Gut. 1995 Mar;36(3):459-61. doi: 10.1136/gut.36.3.459.
Abstract
A 17 year old Asian patient with autoimmune chronic active hepatitis resistant to treatment with high dose corticosteroids and azathioprine was given cyclosporin at a dose of 5 mg/kg/day. Within two weeks of starting the cyclosporin treatment a favourable clinical and biochemical response was obtained and by one month serum aminotransferase activities were within normal limits. An attempted reduction in the daily dose of cyclosporin resulted in a relapse of the patient's disease. Remission was again attained by returning the dose of cyclosporin to 5 mg/kg/day. No significant side effects of the treatment have been shown. Cyclosporin seems to have a role in the treatment of corticosteroid resistant autoimmune chronic active hepatitis and its further evaluation is warranted.
摘要
一名17岁的亚洲自身免疫性慢性活动性肝炎患者，对大剂量皮质类固醇和硫唑嘌呤治疗耐药，给予环孢素，剂量为5毫克/千克/天。开始环孢素治疗两周内，获得了良好的临床和生化反应，到一个月时血清转氨酶活性恢复正常。尝试减少环孢素每日剂量导致患者病情复发。将环孢素剂量恢复到5毫克/千克/天，病情再次缓解。未显示该治疗有明显副作用。环孢素似乎在皮质类固醇耐药的自身免疫性慢性活动性肝炎治疗中发挥作用，值得进一步评估。
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本文引用的文献
1
Natural history, clinical features, and treatment of autoimmune hepatitis.自身免疫性肝炎的自然史、临床特征及治疗
Semin Liver Dis. 1984 Feb;4(1):1-12. doi: 10.1055/s-2008-1040641.
2
Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2.环孢素A通过损害白细胞介素1和白细胞介素2的释放来介导对原发性细胞毒性T细胞反应的免疫抑制。
Eur J Immunol. 1981 Aug;11(8):657-61. doi: 10.1002/eji.1830110812.
3
Adverse effects of azathioprine.硫唑嘌呤的不良反应。
Adverse Drug React Acute Poisoning Rev. 1984 Autumn;3(3):161-71.
4
Cyclosporine-associated chronic nephropathy.环孢素相关慢性肾病
N Engl J Med. 1984 Sep 13;311(11):699-705. doi: 10.1056/NEJM198409133111103.
5
Autosensitization of lymphocytes against thymus reticulum cells.淋巴细胞对胸腺网状细胞的自身致敏作用。
Science. 1972 Jun 23;176(4041):1324-5. doi: 10.1126/science.176.4041.1324.
6
Controlled prospective trial of corticosteroid therapy in active chronic hepatitis.皮质类固醇疗法治疗活动性慢性肝炎的对照前瞻性试验
Q J Med. 1971 Apr;40(158):159-85. doi: 10.1093/oxfordjournals.qjmed.a067264.
7
Long-term results of therapy in patients with chronic liver disease associated with hypergammaglobulinemia.
Am J Med. 1969 Nov;47(5):765-74. doi: 10.1016/0002-9343(69)90169-7.
8
Controlled trial of prednisone and azathioprine in active chronic hepatitis.泼尼松与硫唑嘌呤治疗活动性慢性肝炎的对照试验。
Lancet. 1973 Apr 7;1(7806):735-7. doi: 10.1016/s0140-6736(73)92125-9.
9
Cyclosporin, a new treatment for autoimmune chronic active hepatitis.环孢素，一种治疗自身免疫性慢性活动性肝炎的新疗法。
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10
The effects of cyclosporin A on the immune system.环孢素A对免疫系统的影响。
Annu Rev Immunol. 1985;3:397-423. doi: 10.1146/annurev.iy.03.040185.002145.
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