Jackson L D, Song E
Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa.
Gut. 1995 Mar;36(3):459-61. doi: 10.1136/gut.36.3.459.
A 17 year old Asian patient with autoimmune chronic active hepatitis resistant to treatment with high dose corticosteroids and azathioprine was given cyclosporin at a dose of 5 mg/kg/day. Within two weeks of starting the cyclosporin treatment a favourable clinical and biochemical response was obtained and by one month serum aminotransferase activities were within normal limits. An attempted reduction in the daily dose of cyclosporin resulted in a relapse of the patient's disease. Remission was again attained by returning the dose of cyclosporin to 5 mg/kg/day. No significant side effects of the treatment have been shown. Cyclosporin seems to have a role in the treatment of corticosteroid resistant autoimmune chronic active hepatitis and its further evaluation is warranted.
一名17岁的亚洲自身免疫性慢性活动性肝炎患者，对大剂量皮质类固醇和硫唑嘌呤治疗耐药，给予环孢素，剂量为5毫克/千克/天。开始环孢素治疗两周内，获得了良好的临床和生化反应，到一个月时血清转氨酶活性恢复正常。尝试减少环孢素每日剂量导致患者病情复发。将环孢素剂量恢复到5毫克/千克/天，病情再次缓解。未显示该治疗有明显副作用。环孢素似乎在皮质类固醇耐药的自身免疫性慢性活动性肝炎治疗中发挥作用，值得进一步评估。
