Grevert P, Goldstein A
Psychopharmacology (Berl). 1977 Jul 18;53(2):111-3. doi: 10.1007/BF00426478.
The effect of naloxone on the latency of mice to enter a dark box was determined and the study of Jacob et al. (1974) on the effect of naloxone on hotplate behavior was replicated. Mice took significantly longer to enter a dark box after receiving 10 mg/kg of naloxone than did the saline controls. With the hot-plate technique, at all doses (0.1, 0.3, 1, 3, and 10 mg/kg) except the lowest (0.03 mg/kg), naloxone-treated mice jumped from the hot plate significantly sooner than did the saline controls. No effect of naloxone on paw-lick latency was found. All the data confirm the findings of Jacob et al. (1974). The hotplate results suggest that prolonged exposure to a noxious stimulus may be necessary to activate the endorphin system.
测定了纳洛酮对小鼠进入暗箱潜伏期的影响，并重复了雅各布等人（1974年）关于纳洛酮对热板行为影响的研究。接受10mg/kg纳洛酮的小鼠进入暗箱的时间比生理盐水对照组显著延长。采用热板技术，除最低剂量（0.03mg/kg）外，在所有剂量（0.1、0.3、1、3和10mg/kg）下，接受纳洛酮治疗的小鼠比生理盐水对照组更早从热板上跳下。未发现纳洛酮对舔爪潜伏期有影响。所有数据均证实了雅各布等人（1974年）的研究结果。热板实验结果表明，可能需要长时间暴露于有害刺激才能激活内啡肽系统。
