Men Yutao, Wei Lele, Hu Baibing, Hao Pujun, Zhang Chunqiu
Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control, School of Mechanical Engineering, Tianjin University of Technology, Tianjin 300384, P. R. China.
National Demonstration Center for Experimental Mechanical and Electrical Engineering Education, Tianjin University of Technology, Tianjin 300384, P. R. China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2025 Aug 25;42(4):808-816. doi: 10.7507/1001-5515.202410062.
To assess the implantation effectiveness of porous scaffolds, it is essential to consider not only their mechanical properties but also their biological performance. Given the high cost, long duration and low reproducibility of biological experiments, simulation studies as a virtual alternative, have become a widely adopted and efficient evaluation method. In this study, based on the secondary development environment of finite element analysis software, the strain energy density growth criterion for bone tissue was introduced to simulate and analyze the cell proliferation-promoting effects of four different lattice porous scaffolds under cyclic compressive loading. The biological performance of these scaffolds was evaluated accordingly. The computational results indicated that in the early stages of bone growth, the differences in bone tissue formation among the scaffold groups were not significant. However, as bone growth progressed, the scaffold with a porosity of 70% and a pore size of 900 μm demonstrated markedly superior bone formation compared to other porosity groups and pore size groups. These results suggested that the scaffold with a porosity of 70% and a pore size of 900 μm was most conducive to bone tissue growth and could be regarded as the optimal structural parameter for bone repair scaffold. In conclusion, this study used a visualized simulation approach to pre-evaluate the osteogenic potential of porous scaffolds, aiming to provide reliable data support for the optimized design and clinical application of implantable scaffolds.
为评估多孔支架的植入效果，不仅要考虑其力学性能，还要考虑其生物学性能。鉴于生物实验成本高、周期长且重复性低，模拟研究作为一种虚拟替代方法，已成为广泛采用的高效评估手段。在本研究中，基于有限元分析软件的二次开发环境，引入骨组织的应变能密度增长准则，以模拟和分析四种不同晶格多孔支架在循环压缩载荷下促进细胞增殖的效果。据此对这些支架的生物学性能进行评估。计算结果表明，在骨生长早期，各支架组之间的骨组织形成差异不显著。然而，随着骨生长的进行，孔隙率为70%且孔径为900μm的支架相比其他孔隙率组和孔径组，其骨形成表现出明显优势。这些结果表明，孔隙率为70%且孔径为900μm的支架最有利于骨组织生长，可被视为骨修复支架的最佳结构参数。总之，本研究采用可视化模拟方法对多孔支架的成骨潜力进行预评估，旨在为可植入支架的优化设计和临床应用提供可靠的数据支持。
