Ebrahimzadeh Kaveh, Mirahmadi Eraghi Mohammad, Hallajnejad Mohammad, Mousavian Seyed Taher, Ansari Mohammad, Sabeti Shahram
Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
J Neurosurg Case Lessons. 2025 Sep 1;10(9). doi: 10.3171/CASE25349.
Occlusion of the foramen of Monro is an exceedingly rare condition in adults and can lead to obstructive hydrocephalus. The authors present the first reported case of biventricular hydrocephalus caused by tuberculosis-induced bilateral obstruction of the foramen of Monro. They also discuss the technical nuances and surgical challenges associated with this condition.
A 47-year-old female presented with a 3-month history of short-term memory disturbances, ultimately leading to loss of consciousness. Neuroimaging revealed symmetrical biventricular hydrocephalus accompanied by periventricular interstitial edema. A lumbar puncture indicated lymphocytic-dominant pleocytosis and reduced glucose levels. During the endoscopic approach, significant stenosis of the foramen of Monro was noticed and monroplasty and septostomy were performed. Pathological examination revealed granulomatous inflammation. At the 1-year follow-up, the patient demonstrated significant clinical and radiological improvement, with resolution of symptoms and hydrocephalus.
Tuberculosis-induced bilateral idiopathic occlusion of the foramen of Monro is an extremely uncommon cause of hydrocephalus. Neuroendoscopy allows for visualization, biopsy, and direct treatment of the obstruction simultaneously. While conservative management may be adequate for asymptomatic cases, neuroendoscopic procedures such as septostomy or foraminoplasty provide a minimally invasive option for restoring CSF flow, avoiding unnecessary shunt insertion in symptomatic cases. https://thejns.org/doi/10.3171/CASE25349.
孟氏孔闭塞在成人中极为罕见,可导致梗阻性脑积水。作者报告了首例由结核引起的双侧孟氏孔梗阻导致的双侧脑室积水病例。他们还讨论了与这种情况相关的技术细节和手术挑战。
一名47岁女性,有3个月短期记忆障碍病史,最终导致意识丧失。神经影像学检查显示双侧脑室对称积水,伴有脑室周围间质水肿。腰椎穿刺显示淋巴细胞为主的细胞增多和葡萄糖水平降低。在内镜手术过程中,发现孟氏孔明显狭窄,并进行了孟氏孔成形术和中隔造瘘术。病理检查显示肉芽肿性炎症。在1年的随访中,患者在临床和影像学上有显著改善,症状和脑积水均得到缓解。
结核引起的双侧特发性孟氏孔闭塞是脑积水极为罕见的原因。神经内镜检查可同时实现对梗阻的可视化、活检和直接治疗。对于无症状病例,保守治疗可能就足够了,而对于有症状的病例,中隔造瘘术或孔成形术等神经内镜手术为恢复脑脊液流动提供了一种微创选择,避免了不必要的分流置入。https://thejns.org/doi/10.3171/CASE25349。