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脑静脉血栓形成所致颅内高压继发急性双侧视力丧失:一例报告

Acute bilateral vision loss secondary to cerebral venous thrombosis-induced intracranial hypertension: a case report.

作者信息

Panigrahi Pradeep Kumar, Sahoo Srikanta Kumar, Gayathri Kathasagaram Aruna, Mishra Suchismita

机构信息

Department of Ophthalmology, Institute of Medical Sciences & SUM Hospital, Siksha O Anusandhan (deemed to be) University, 8-Kalinga Nagar, Bhubaneswar, 751003, India.

Department of Neurology, Institute of Medical Sciences & SUM Hospital, Siksha O Anusandhan (deemed to be) University, 8-Kalinga Nagar, Bhubaneswar, 751003, India.

出版信息

BMC Ophthalmol. 2025 Sep 1;25(1):493. doi: 10.1186/s12886-025-04332-0.

Abstract

BACKGROUND

The present case describes a rare presentation of sudden onset acute bilateral vision loss due to cerebral venous thrombosis secondary to malignant rise in intracranial pressure.

CASE PRESENTATION

A 23-year-old male patient presented with sudden onset bilateral loss of vision of one week duration. Best-corrected visual acuity was 6/18, N12, and perception of light in the right and left eye, respectively. Fundus examination revealed papilledema. Magnetic resonance imaging showed thrombotic occlusion of the superior sagittal, straight, and inferior sagittal sinuses. Cerebrospinal fluid opening pressure was elevated to 40 cm HO. Laboratory investigations showed the presence of polycythemia (Hemoglobin- 18.6 g/dl) and elevated serum homocysteine (38.64 µmol/L) levels. Early initiation of appropriate treatment resulted in improvement of vision to 6/9, N8 and 6/6, N6 in the right and left eye, respectively. One month following treatment, there was complete resolution of papilledema and retinal haemorrhages in both eyes.

CONCLUSION

Malignant rise in intracranial pressure can rarely lead to the sudden onset bilateral vision loss. Early diagnosis and prompt treatment can be associated with a good visual prognosis.

摘要

背景

本病例描述了一种罕见的表现,即由于颅内压恶性升高继发脑静脉血栓形成导致的急性双侧视力突然丧失。

病例介绍

一名23岁男性患者出现突发双侧视力丧失,持续一周。最佳矫正视力分别为右眼6/18、N12,左眼光感。眼底检查发现视乳头水肿。磁共振成像显示上矢状窦、直窦和下矢状窦血栓形成性闭塞。脑脊液初压升高至40cmH₂O。实验室检查显示存在红细胞增多症(血红蛋白-18.6g/dl)和血清同型半胱氨酸水平升高(38.64µmol/L)。早期开始适当治疗后,视力分别改善为右眼6/9、N8,左眼6/6、N6。治疗后一个月,双眼视乳头水肿和视网膜出血完全消退。

结论

颅内压恶性升高很少导致突发双侧视力丧失。早期诊断和及时治疗可能与良好的视力预后相关。

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