Nguyen Binh Huy, Tran Nhung Thi Cam, Ho Chuong Quoc, Tran Tam Thai Thanh, Phan Hong Ngoc, Tran De Van, Pham Nga Thi Ngoc, Nguyen Kien Trung, Pham Khanh Hoang
Department of Physiology, Faculty of Medicine, Hanoi Medical University, Vietnam.
Department of Anesthesia and Resuscitation, Can Tho Stroke International Services, Vietnam.
J Int Med Res. 2025 Sep;53(9):3000605251372069. doi: 10.1177/03000605251372069. Epub 2025 Sep 2.
ObjectivesGenome-wide association studies have identified as a gene linked to chronic obstructive pulmonary disease. Several single-nucleotide polymorphisms-notably, rs7671167, rs2869967, rs2869966, and rs17014601-are associated with chronic obstructive pulmonary disease susceptibility and spirometric indices. This study aimed to investigate the association between single-nucleotide polymorphisms and spirometric indices in chronic obstructive pulmonary disease and non-chronic obstructive pulmonary disease patients and assess the correlation of these single-nucleotide polymorphisms with pulmonary ventilation function.MethodsThis study included 160 participants (80 chronic obstructive pulmonary disease patients and 80 controls) who underwent clinical evaluation and spirometry at Can Tho University of Medicine and Pharmacy Hospital from March 2021 to February 2023.ResultsThe mean patient age was 66.3 ± 7.9 years. Significant differences in allele frequencies of the studied single-nucleotide polymorphisms were observed between the two groups. TT genotypes at rs7671167 and rs17014601 and CT genotypes at rs7671167, rs2869967, and rs2869966 were associated with significant differences in forced vital capacity, forced expiratory volume in 1 second, and Tiffeneau index.ConclusionThe CT genotype at rs7671167, rs2869967, and rs2869966 is significantly associated with altered spirometric parameters, suggesting a role in chronic obstructive pulmonary disease-related lung function impairment.
目的
全基因组关联研究已确定[具体基因名称未给出]为与慢性阻塞性肺疾病相关的基因。几个单核苷酸多态性——特别是rs7671167、rs2869967、rs2869966和rs17014601——与慢性阻塞性肺疾病易感性和肺量计指标相关。本研究旨在调查[具体基因名称未给出]单核苷酸多态性与慢性阻塞性肺疾病患者和非慢性阻塞性肺疾病患者肺量计指标之间的关联，并评估这些单核苷酸多态性与肺通气功能的相关性。
方法
本研究纳入了160名参与者（80名慢性阻塞性肺疾病患者和80名对照），他们于2021年3月至2023年2月在芹苴医科大学医院接受了临床评估和肺量计检查。
结果
患者的平均年龄为66.3±7.9岁。在两组之间观察到所研究的单核苷酸多态性的等位基因频率存在显著差异。rs7671167和rs17014601的TT基因型以及rs7671167、rs2869967和rs2869966的CT基因型与用力肺活量、第1秒用力呼气量和蒂芬诺指数的显著差异相关。
结论
rs7671167、rs2869967和rs2869966的CT基因型与肺量计参数改变显著相关，提示其在慢性阻塞性肺疾病相关肺功能损害中起作用。
