Seggie J, Werstiuk E S, Joshi M
Prog Neuropsychopharmacol Biol Psychiatry. 1985;9(5-6):755-8. doi: 10.1016/0278-5846(85)90055-7.
Lithium, a widely used substance for the treatment of manic-depressive illness, has been reported to alter the phase relationships of a variety of biological rhythms. We have previously found that lithium affects serum melatonin differently in albino compared to pigmented eye rats. The present study was undertaken to investigate the effect of lithium on pituitary rhythms in pigmented eye rats. Six point 24 hour maps were generated throughout a 12 hour light/12 hour dark lighting regime on separate groups of individually housed adult male Long Evans rats (with pigmented eyes), maintained for six weeks on ad lib water and either normal lab chow or lab chow supplemented with 50 mM/Kg of lithium chloride. Animals were sacrificed by rapid decapitation with care to ensure that blood samples were obtained from subjects in the resting, undisturbed state. Plasma lithium levels were 0.57 +/- 0.02 mEq/1. In comparison to normal controls, lithium treatment suppressed body weight by 19%, and increased water intake by 100%. Absolute corticosterone levels were not altered by lithium, but the 24-hour pattern was significantly changed. Growth hormone levels were significantly reduced by lithium treatment without alteration of the 24-hour pattern. Prolactin levels were significantly reduced by lithium and the normal 24-hour variation was attenuated. Comparison of these effects of lithium in pigmented eye rats with similar data from albino rats suggests that the effects on growth hormone, body weight and water intake were similar; however, the effects on prolactin and corticosterone differed.(ABSTRACT TRUNCATED AT 250 WORDS)
锂是一种广泛用于治疗躁郁症的物质，据报道它会改变多种生物节律的相位关系。我们之前发现，与有色眼大鼠相比，锂对白化大鼠血清褪黑素的影响有所不同。本研究旨在调查锂对有色眼大鼠垂体节律的影响。在12小时光照/12小时黑暗的光照条件下，对单独饲养的成年雄性长 Evans 大鼠（有色眼）的不同组生成六个时间点的24小时图谱，这些大鼠自由饮水，并喂食普通实验室饲料或添加了50 mM/Kg 氯化锂的实验室饲料，持续六周。通过快速断头处死动物，注意确保从处于休息、未受干扰状态的动物身上采集血样。血浆锂水平为0.57 +/- 0.02 mEq/1。与正常对照组相比，锂治疗使体重下降了19%，饮水量增加了100%。锂并未改变皮质酮的绝对水平，但24小时模式发生了显著变化。锂治疗使生长激素水平显著降低，但未改变24小时模式。锂使催乳素水平显著降低，正常的24小时变化减弱。将锂对有色眼大鼠的这些影响与白化大鼠的类似数据进行比较表明，对生长激素、体重和饮水量的影响相似；然而，对催乳素和皮质酮的影响有所不同。（摘要截短至250字）
