Berestova Anna, Savina Tamara, Semenycheva Irina, Kozhemov Sultanbek
Institute of Clinical Morphology and Digital Pathology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.
Department of Polyclinic Therapy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation.
Clin Oral Investig. 2025 Sep 2;29(9):434. doi: 10.1007/s00784-025-06515-x.
BACKGROUND/PURPOSE: This study investigated the clinical and histological characteristics of oral mucosal lesions in children with acute respiratory viral infections (ARVI) and Asthma (BA)-conditions that frequently coexist and exacerbate mucosal damage.
The rationale for the study stems from the lack of comprehensive data on the combined impact of these diseases on oral health. A total of 200 children aged 5-12 years were examined in a hospital setting and divided into 4 equal groups: children with ARVI (Group 1), children with Asthma (Group 2), children with both conditions (Group 3), and healthy children (control Group 4). The experimental design included clinical assessment, mucosal biopsy, histological examination, and quality-of-life evaluation using validated questionnaires.
Results showed that children in Group 3 (ARVI + BA) exhibited significantly more severe mucosal damage, including pronounced hyperemia (3.0 ± 0.5), increased erosions (4.5 ± 1.1), and higher pain scores (3.5 ± 0.6) compared to Groups 1 and 2. The control group (Group 4) showed minimal changes. Histological analysis revealed greater epithelial atrophy and inflammatory infiltration in Group 3.
These findings highlight the need for tailored therapeutic approaches in children with coexisting ARVI and Asthma to mitigate oral mucosal damage and improve overall health outcomes. The study addressed the lack of comprehensive data on the combined effects of ARVI and asthma on oral health, with findings revealing more pronounced mucosal damage in children with both conditions compared to those with only one.
背景/目的：本研究调查了急性呼吸道病毒感染（ARVI）和哮喘（BA）患儿口腔黏膜病变的临床和组织学特征，这两种疾病常同时存在并加重黏膜损伤。
该研究的理论依据源于缺乏关于这些疾病对口腔健康综合影响的全面数据。在医院环境中对总共200名5至12岁的儿童进行了检查，并将其分为4个相等的组：ARVI患儿（第1组）、哮喘患儿（第2组）、患有这两种疾病的患儿（第3组）和健康儿童（对照组第4组）。实验设计包括临床评估、黏膜活检、组织学检查以及使用经过验证的问卷进行生活质量评估。
结果显示，与第1组和第2组相比，第3组（ARVI + BA）的患儿黏膜损伤明显更严重，包括明显的充血（3.0±0.5）、糜烂增加（4.5±1.1）和更高的疼痛评分（3.5±0.6）。对照组（第4组）变化最小。组织学分析显示第3组上皮萎缩和炎症浸润更严重。
这些发现凸显了对同时患有ARVI和哮喘的患儿采取针对性治疗方法以减轻口腔黏膜损伤并改善整体健康结果的必要性。该研究解决了关于ARVI和哮喘对口腔健康综合影响缺乏全面数据的问题，研究结果显示，与仅患有一种疾病的儿童相比，同时患有这两种疾病的儿童黏膜损伤更明显。
