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脑损伤恢复中的适应性神经可塑性:策略与见解

Adaptive Neuroplasticity in Brain Injury Recovery: Strategies and Insights.

作者信息

Zotey Vaishnavi, Andhale Amol, Shegekar Tejas, Juganavar Anup

机构信息

Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.

出版信息

Cureus. 2023 Sep 24;15(9):e45873. doi: 10.7759/cureus.45873. eCollection 2023 Sep.

Abstract

This review addresses the relationship between neuroplasticity and recovery from brain damage. Neuroplasticity's ability to adapt becomes crucial since brain injuries frequently result in severe impairments. We begin by describing the fundamentals of neuroplasticity and how it relates to rehabilitation. Examining different forms of brain injuries and their neurological effects highlights the complex difficulties in rehabilitation. By revealing cellular processes, we shed light on synaptic adaptability following damage. Our study of synaptic plasticity digs into axonal sprouting, dendritic remodeling, and the balance of long-term potentiation. These processes depict neural resilience amid change. Then, after damage, we investigate immediate and slow neuroplastic alterations, separating reorganizations that are adaptive from those that are maladaptive. As we go on to rehabilitation, we evaluate techniques that use neuroplasticity's potential. These methods take advantage of the brain's plasticity for healing, from virtual reality and brain-computer interfaces to constraint-induced movement therapy. Ethics and individualized neurorehabilitation are explored. We scrutinize the promise of combination therapy and the difficulties in putting new knowledge into clinical practice. In conclusion, this analysis highlights neuroplasticity's critical role in brain injury recovery, providing sophisticated approaches to improve life after damage.

摘要

本综述探讨了神经可塑性与脑损伤恢复之间的关系。由于脑损伤常常导致严重的功能障碍,神经可塑性的适应能力就变得至关重要。我们首先描述神经可塑性的基本原理及其与康复的关系。研究不同形式的脑损伤及其神经学影响,凸显了康复过程中复杂的困难。通过揭示细胞过程,我们阐明了损伤后突触的适应性。我们对突触可塑性的研究深入探讨了轴突发芽、树突重塑以及长时程增强的平衡。这些过程描绘了变化中的神经弹性。然后,在损伤后,我们研究即时和缓慢的神经可塑性改变,区分适应性重组和非适应性重组。在进入康复阶段后,我们评估利用神经可塑性潜力的技术。这些方法利用大脑的可塑性进行治疗,从虚拟现实和脑机接口到强制性运动疗法。我们还探讨了伦理和个性化神经康复。我们审视联合治疗的前景以及将新知识应用于临床实践的困难。总之,本分析突出了神经可塑性在脑损伤恢复中的关键作用,提供了改善损伤后生活的复杂方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a6d/10598326/e0daa672c68a/cureus-0015-00000045873-i01.jpg

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