Zhao Nan, Zhu Zhao-Qiong, Gong Qihai, Jiang Rui
Department of Anesthesiology, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi 563003, China.
Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China.
IBRO Neurosci Rep. 2025 Aug 15;19:445-455. doi: 10.1016/j.ibneur.2025.08.011. eCollection 2025 Dec.
This study aims to analyze the research hotspots and trends regarding neuroinflammation in sleep disorders over the past 30 years through bibliometric and review analyses. Relevant publications were sourced from the Web of Science Core Collection (WoSCC). We utilized VOSviewer and CiteSpace for the visualization and quantitative analysis of the literature to provide an objective presentation and predictions. A total of 2545 publications related to neuroinflammation and sleep disorders were identified, with the overall number of publications showing a continuous upward trend. Most of the publications originated from the United States and China. The University of Toronto, Harvard Medical School, and the University of California, Los Angeles, are leading institutions in this field. David Gozal and Michael R. Irwin are recognized as prominent figures in this area. The and are the journals with the highest publication volume. Keywords and clustering analyses indicate that the current research in this field has developed a multidisciplinary integration pattern, with core trends focusing on the multi-axis regulation of neuroimmune interaction mechanisms, as well as individualized targeted intervention strategies based on biomarkers and gene editing. Additionally, the development of emerging technologies such as organoids and the establishment of multidisciplinary collaborative networks bring new hope for exploring the interactions between neuroinflammation and sleep disorders.
本研究旨在通过文献计量学和综述分析，剖析过去30年睡眠障碍中神经炎症的研究热点和趋势。相关出版物来源于科学网核心合集（WoSCC）。我们利用VOSviewer和CiteSpace对文献进行可视化和定量分析，以提供客观的呈现和预测。共识别出2545篇与神经炎症和睡眠障碍相关的出版物，出版物总数呈持续上升趋势。大多数出版物来自美国和中国。多伦多大学、哈佛医学院和加利福尼亚大学洛杉矶分校是该领域的领先机构。大卫·戈扎尔和迈克尔·R·欧文被公认为该领域的杰出人物。《 》和《 》是发表量最高的期刊。关键词和聚类分析表明，该领域目前的研究已形成多学科整合模式，核心趋势集中在神经免疫相互作用机制的多轴调节，以及基于生物标志物和基因编辑的个体化靶向干预策略。此外，类器官等新兴技术的发展以及多学科协作网络的建立，为探索神经炎症与睡眠障碍之间的相互作用带来了新希望。
