Yan Hailan, Li Xiaoyan, Dai Yi, Shi Jinghua, Wu Yushi, Gu Zhiyue, Zhang Chenyu, Li Qiutong, Zhang Biyun, Lyu Shiqing, Leng Jinhua
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, China.
Front Med (Lausanne). 2025 Aug 14;12:1562196. doi: 10.3389/fmed.2025.1562196. eCollection 2025.
Endometriosis is a common, chronic, estrogen-dependent gynecological disorder that significantly affects patients' quality of life. However, the disease burden and its trends may be undergoing significant changes, and comprehensive data on this issue are currently lacking. This study aimed to examine trends in the burden of endometriosis at the global, national, and regional levels.
We collected detailed data on incidence numbers, disability-adjusted life years (DALYs), age-standardized incidence rate (ASIR), and age-standardized DALY rate (ASDR) for the period 1990-2021 from the GBD 2021 database. We calculated the estimated annual percentage changes (EAPCs) to quantify the temporal trends in the ASIR and ASDR of endometriosis and presented the global distribution of these trends.
The global incident cases of endometriosis were 3.45 million (95% uncertainty interval [UI] = 2.44 to 4.6), and DALYs were 2.05 million (95% UI = 1.20 to 3.13). The global ASIR decreased from 1990 to 2021 (EAPC = -1.01, 95% UI = -1.06 to -0.96), while the ASDR was similar (EAPC = -0.99, 95% UI = -1.04 to -0.95). The age groups with the highest global incidence and DALYs were 20-24 and 25-29 years. The highest 2021 ASIR and ASDR were both in Niger (77.33 per 100,000 individuals, 95% UI = 52.74 to 106.78; 61.45 per 100,000 individuals, 95% UI = 34.29 to 95.47) and in Oceania (77.71 per 100,000 individuals, 95% UI = 51.23 to 100.27; 45.24 per 100,000 individuals, 95% UI = 45.24 to 71.95). In 2021, the ASIR and ASDR were highest in the low sociodemographic index (SDI) region. We also found that the EAPC was negatively correlated with ASIR in 1990 ( = -0.55, < 0.001) and positively correlated with Human Development Index (HDI) in 2021 ( = 0.556, < 0.001).
The global burden of endometriosis remains substantial and has continued to rise across most countries, territories, and regions since the 1990s, underscoring the urgent need for targeted public health strategies and advancements in diagnosis and treatment to address this pervasive condition.
子宫内膜异位症是一种常见的、慢性的、雌激素依赖性妇科疾病，严重影响患者的生活质量。然而，疾病负担及其趋势可能正在发生显著变化，目前缺乏关于这一问题的全面数据。本研究旨在探讨全球、国家和区域层面子宫内膜异位症负担的趋势。
我们从全球疾病负担研究（GBD）2021数据库收集了1990 - 2021年期间发病率、伤残调整生命年（DALYs）、年龄标准化发病率（ASIR）和年龄标准化DALY率（ASDR）的详细数据。我们计算了估计年变化百分比（EAPCs）以量化子宫内膜异位症ASIR和ASDR的时间趋势，并呈现这些趋势的全球分布情况。
全球子宫内膜异位症发病例数为345万（95%不确定区间[UI] = 244万至460万），DALYs为205万（95% UI = 120万至313万）。1990年至2021年全球ASIR下降（EAPC = -1.01，95% UI = -1.06至 -0.96），而ASDR相似（EAPC = -0.99，95% UI = -1.0
