Zhang Jie, Yang Chun, Xiong Jian, Qian Hongyu, Xie Yuanyuan, Xie Shunkai, Luo Yi, Yu Jianhong, Yu Hai, Xu Jing
College of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, People's Republic of China.
Diabetes Metab Syndr Obes. 2025 Aug 24;18:2995-3013. doi: 10.2147/DMSO.S514613. eCollection 2025.
Obesity is a highly prevalent metabolic disorder that significantly increases the risk of cardiovascular and cerebrovascular diseases. Acupuncture has demonstrated remarkable efficacy in treating obesity, offering substantial societal health benefits.
Electroacupuncture has shown promise in the treatment of obesity (OB). The development of obesity is directly linked to the gut microbiota. Therefore, we aimed to explore the mechanism by which electroacupuncture alleviates obesity induced by a high-fat diet (HFD) by modulating the gut microbiota.
Fifty specific pathogen-free Sprague-Dawley (male) rats were obtained, and 44 rats were randomly selected and subjected to an HFD. The remaining six rats were used as controls and subjected to a basic diet. The successfully-induced-obese rats were randomly divided into four groups: the obese group (n=6), the obese+electroacupuncture group (n=6), the obese+antibiotic group (n=6), and the obese+antibiotic+electroacupuncture group (n=6). Furthermore, the weight-reducing effect of electroacupuncture was investigated in HFD-induced obese rats by monitoring their body weight, food consumption, Lee's index, blood fat, and liver steatosis. The levels of 5-hydroxytryptamine (5-HT), gut microbiota composition, and short-chain fatty acid content were measured and characterized.
Electroacupuncture significantly reduced body weight in obese rats and alleviated lipid metabolism disorders. Furthermore, it also improved the number, abundance, and structure of the gut microbiota in obese rats and increased acetic acid and 5-HT content. Moreover, Lactobacillus faecis (L. faecis) and Bacteroides fragilis (B. fragilis) were correlated with obesity-related indicators, acetic acid levels, and 5-HT content.
Electroacupuncture may exert anti-obesity effects by modulating acetic acid levels and 5-HT release by intestinal enterochromaffin cells. L. faecis and B. fragilis in the gut microbiota may be potential targets for the treatment of obesity in the future.
肥胖是一种高度流行的代谢紊乱疾病，显著增加了心血管和脑血管疾病的风险。针灸在治疗肥胖方面已显示出显著疗效，为社会健康带来了巨大益处。
电针在肥胖症（OB）治疗中显示出前景。肥胖的发展与肠道微生物群直接相关。因此，我们旨在探讨电针通过调节肠道微生物群减轻高脂饮食（HFD）诱导的肥胖的机制。
获取50只特定病原体-free的Sprague-Dawley雄性大鼠，随机选取44只大鼠给予高脂饮食。其余6只大鼠作为对照，给予基础饮食。成功诱导肥胖的大鼠随机分为四组：肥胖组（n = 6）、肥胖+电针组（n = 6）、肥胖+抗生素组（n = 6）和肥胖+抗生素+电针组（n = 6）。此外，通过监测高脂饮食诱导的肥胖大鼠的体重、食物消耗、李氏指数、血脂和肝脏脂肪变性，研究电针的减肥效果。测量并表征5-羟色胺（5-HT）水平、肠道微生物群组成和短链脂肪酸含量。
电针显著降低肥胖大鼠的体重，减轻脂质代谢紊乱。此外，它还改善了肥胖大鼠肠道微生物群的数量、丰度和结构，并增加了乙酸和5-HT含量。此外，粪肠球菌（L. faecis）和脆弱拟杆菌（B. fragilis）与肥胖相关指标、乙酸水平和5-HT含量相关。
电针可能通过调节乙酸水平和肠道肠嗜铬细胞释放5-HT发挥抗肥胖作用。肠道微生物群中的粪肠球菌和脆弱拟杆菌可能是未来治疗肥胖的潜在靶点。
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