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来自……的多糖对……中短链脂肪酸产生和群体感应的影响

Influence of Polysaccharides From on Short-Chain Fatty Acid Production and Quorum Sensing in .

作者信息

Yang Min, Meng Fanying, Gu Wen, Fu Lihui, Zhang Fan, Li Fengjiao, Tao Yating, Zhang Zhengyang, Wang Xi, Yang Xingxin, Li Jingping, Yu Jie

机构信息

Yunnan Key Laboratory of Southern Medicine Utilization, College of Pharmaceutical Science, Yunnan University of Chinese Medicine, Kunming, China.

Kunming Third People's Hospital, Kunming, China.

出版信息

Front Microbiol. 2021 Nov 17;12:758870. doi: 10.3389/fmicb.2021.758870. eCollection 2021.

DOI:10.3389/fmicb.2021.758870
PMID:34867887
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8635744/
Abstract

Polysaccharide is one of the main active ingredients of , which has been proven to regulate the balance of gut microbiota. For the first time, this study focused on the regulation of polysaccharides from (PS) on , a specific probiotic in the intestinal tract. PS effectively promoted the biomass, biofilm and acetic acid production in 2-84, and enhanced quorum sensing (QS) signaling. The characteristics of gene sequence were analyzed using genomics approaches, and 2-84 was found to encode 18 genes that are closely related to QS and 10 genes related to short-chain fatty acids (SCFAs). Additionally, transcriptome and proteome analysis demonstrated that PS could promote the QS system of by enhancing the transcription of gene and expression of oppD protein. PS also regulated the production and metabolism of SCFAs of by upregulating the expression of and gene and adh2 protein, and downregulating the expression of gene. In conclusion, it was speculated that PS could affect intestinal SCFAs production by affecting the QS system and SCFAs production in . The present study implied that PS might have a role in promoting the growth of intestinal probiotics, where the QS system and SCFAs might be two of the important mechanisms for the probiotic activity of PS.

摘要

多糖是[具体物质]的主要活性成分之一，已被证明可调节肠道微生物群的平衡。本研究首次聚焦于[具体物质]中的多糖（PS）对肠道中一种特定益生菌[具体益生菌名称]的调节作用。PS有效促进了[具体益生菌名称]2 - 84的生物量、生物膜形成及乙酸产生，并增强了群体感应（QS）信号。利用基因组学方法分析了基因序列特征，发现[具体益生菌名称]2 - 84编码18个与QS密切相关的基因和10个与短链脂肪酸（SCFAs）相关的基因。此外，转录组和蛋白质组分析表明，PS可通过增强[具体基因名称]基因的转录和oppD蛋白的表达来促进[具体益生菌名称]的QS系统。PS还通过上调[具体基因名称1]和[具体基因名称2]基因及adh2蛋白的表达，下调[具体基因名称3]基因的表达来调节[具体益生菌名称]的SCFAs产生和代谢。总之，推测PS可能通过影响[具体益生菌名称]的QS系统和SCFAs产生来影响肠道SCFAs的产生。本研究表明，PS可能在促进肠道益生菌生长方面发挥作用，其中QS系统和SCFAs可能是PS益生菌活性的两个重要机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c2a/8635744/ab3f7ead53ea/fmicb-12-758870-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c2a/8635744/df4c83e721c8/fmicb-12-758870-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c2a/8635744/e78d9123c51d/fmicb-12-758870-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c2a/8635744/20eb2f57d2ef/fmicb-12-758870-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c2a/8635744/a0caad2889ff/fmicb-12-758870-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c2a/8635744/c873551c04dd/fmicb-12-758870-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c2a/8635744/ab3f7ead53ea/fmicb-12-758870-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c2a/8635744/df4c83e721c8/fmicb-12-758870-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c2a/8635744/e78d9123c51d/fmicb-12-758870-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c2a/8635744/20eb2f57d2ef/fmicb-12-758870-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c2a/8635744/a0caad2889ff/fmicb-12-758870-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c2a/8635744/c873551c04dd/fmicb-12-758870-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c2a/8635744/ab3f7ead53ea/fmicb-12-758870-g006.jpg

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