Phenomics. 2025 Apr 1;5(3):311-325. doi: 10.1007/s43657-024-00170-0. eCollection 2025 Jun.
Molecular characterization of a biological sample, e.g., with omics approaches, is fundamental for the development and implementation of personalized and precision medicine approaches. In this context, quality assessment is one of the most critical aspects. Accurate performance and interpretation of omics techniques is based on consensus, harmonization, and standardization of protocols, procedures, data analysis and reference values and materials. EATRIS, the European Infrastructure for Translational Medicine (www.EATRIS.eu), brings together resources and services to support researchers in developing their biomedical discoveries into novel translational tools and interventions for better health outcomes. Here we describe the efforts within the Horizon 2020 EATRIS-Plus project and activities of member facilities of EATRIS towards quality assessment of pre-clinical sample processing, clinical omics data generation, multi-omics data integration, and dissemination of the resources in a Multi-Omics Toolbox, which is the principal deliverable of the EATRIS-Plus project for the consolidation of EATRIS towards translational medicine.
The online version contains supplementary material available at 10.1007/s43657-024-00170-0.
使用组学方法对生物样本进行分子特征分析是个性化和精准医学方法开发与实施的基础。在此背景下，质量评估是最关键的方面之一。组学技术的准确性能和解释基于方案、程序、数据分析以及参考值和材料的共识、协调与标准化。欧洲转化医学基础设施（www.EATRIS.eu）汇聚资源和服务，以支持研究人员将其生物医学发现转化为新型转化工具和干预措施，从而实现更好的健康结果。在此，我们描述了“地平线2020”EATRIS-Plus项目中的工作以及EATRIS成员机构在临床前样本处理质量评估、临床组学数据生成、多组学数据整合以及在多组学工具箱中传播资源方面的活动，多组学工具箱是EATRIS-Plus项目为推动EATRIS向转化医学发展的主要交付成果。
在线版本包含可在10.1007/s43657-024-00170-0获取的补充材料。
