Parreira A, Robinson D S, Melo J V, Ayliffe M, Ball S, Hegde U, Baughan A, Fairhead S, Talavera J G, Katzmann J A
Scand J Haematol. 1985 Nov;35(5):570-8. doi: 10.1111/j.1600-0609.1985.tb02830.x.
The clinical and laboratory studies of 6 patients with primary plasma cell leukaemia are described. The leukaemic cells had a variable morphology, ranging from lymphoplasmacytic and mature plasma cells to poorly differentiated blasts. The neoplastic plasma cells had a characteristic phenotype: they were positive for CyIg and the McAb OKT10 and Ri-3, and did not express the B-cell antigens Ia, B1 and B4. Ultrastructural studies confirmed the plasma cell nature of the leukaemic cells and showed the presence of a meshwork of cytoplasmic fibrils in 50 to 90% of the neoplastic cells from all cases. The distinct ultrastructural and immunological features of PCL described in this study will help the diagnosis and further characterisation of this disease entity.
本文描述了6例原发性浆细胞白血病患者的临床和实验室研究情况。白血病细胞形态各异，从淋巴浆细胞和成熟浆细胞到分化不良的原始细胞都有。肿瘤性浆细胞具有特征性表型：它们对胞质免疫球蛋白（CyIg）、单克隆抗体OKT10和Ri-3呈阳性，且不表达B细胞抗原Ia、B1和B4。超微结构研究证实了白血病细胞的浆细胞性质，并显示所有病例中50%至90%的肿瘤细胞存在细胞质纤维网络。本研究中描述的原发性浆细胞白血病独特的超微结构和免疫学特征将有助于该疾病实体的诊断和进一步特征描述。
