Hirashima Junya, Saito Miyoko, Igarashi Hirotaka, Takagi Satoshi, Hasegawa Daisuke
Laboratory of Small Animal Surgery (Neurology), School of Veterinary Medicine, Azabu University, Sagamihara, Japan.
Laboratory of Small Animal Internal Medicine, School of Veterinary Medicine, Azabu University, Sagamihara, Japan.
Front Vet Sci. 2021 Jul 20;8:708407. doi: 10.3389/fvets.2021.708407. eCollection 2021.
A vagus nerve stimulation (VNS) system was surgically implanted to treat drug-resistant epilepsy in a 5-year-old male Shetland Sheepdog. At regular visits during a 1-year follow-up, treatment efficacy and adverse effects were assessed, and programmable stimulation parameters were adjusted to optimize stimulation intensity while avoiding adverse effects. The frequency of generalized tonic-clonic seizures was reduced by 87% after the initiation of VNS. The owner reported that the dog regained his personality, and the quality of life of both the dog and owner improved. The only adverse effect of VNS was a cough that was controlled by adjusting stimulation parameters. There were no surgical complications or other issues with the VNS device. This is the first long-term evaluation of VNS therapy in a dog, and the results obtained suggest that gradual adjustments of VNS parameters facilitate optimum VNS dosing.
为治疗一名5岁雄性设得兰牧羊犬的耐药性癫痫，通过手术植入了迷走神经刺激（VNS）系统。在1年的随访期间定期就诊时，评估治疗效果和不良反应，并调整可编程刺激参数以优化刺激强度，同时避免不良反应。开始VNS治疗后，全身性强直阵挛性癫痫发作的频率降低了87%。主人报告称，这只狗恢复了个性，狗和主人的生活质量都得到了改善。VNS的唯一不良反应是咳嗽，可通过调整刺激参数来控制。VNS设备没有出现手术并发症或其他问题。这是对狗进行VNS治疗的首次长期评估，所得结果表明，逐渐调整VNS参数有助于实现最佳的VNS给药剂量。
