超声疗法缓解2型糖尿病女性运动引起的肌肉酸痛和疲劳：一项随机对照试验
Ultrasound therapy for exercise-induced muscle soreness and fatigue relief in women with type 2 diabetes: a randomized controlled trial.
作者信息
Bameri Tahereh, Rezaeipour Mohammadreza, Nakhzari Khodakheir Javad
机构信息
Sport Sciences Department, University of Sistan and Baluchestan, Zahedan, Iran.
Sport Sciences Department, University of Sistan and Baluchestan, Zahedan 9816745845, Iran.
出版信息
Ther Adv Endocrinol Metab. 2025 Aug 29;16:20420188251362091. doi: 10.1177/20420188251362091. eCollection 2025.
BACKGROUND
Exercise-induced muscle soreness and fatigue are significant barriers to physical activity in middle-aged women with type 2 diabetes (T2D), exacerbated by impaired tissue healing and chronic inflammation.
OBJECTIVES
To evaluate whether post-exercise therapeutic ultrasound (TUS) effectively reduces exercise-induced muscle soreness and fatigue while improving metabolic and inflammatory biomarkers in women with T2D.
DESIGN
Randomized controlled trial.
METHODS
Thirty sedentary women with T2D (aged 41-49 years, glycated hemoglobin (HbA1c) 6.5%-9.0%) were randomized to a TUS group ( = 15) or control ( = 15). Both groups completed an 8-week aerobic cycling program (3 sessions/week, 45 min/session, 60%-70% VOmax). The TUS group received post-exercise ultrasound (3 MHz, 1 W/cm, 7 min/leg) using the Intellect Mobile 2 device. Primary outcomes were pain (Von Korff scale) and fatigue (Borg scale), while secondary outcomes included fasting blood sugar (FBS), HbA1c, inflammatory markers (tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6)), and creatine kinase (CK), assessed at baseline and post-intervention. Linear mixed-effects models adjusted for baseline pain differences.
RESULTS
The TUS group showed marked decreases in pain (-2.2, 95% CI: -2.8 to -1.6, < 0.001) and fatigue (-1.8, 95% CI: -2.4 to -1.2, = 0.004) compared to controls. Secondary outcomes substantially improved: HbA1c (-0.5%, = 0.03), FBS (-19.8 mg/dL, = 0.01), TNF-α (-24.9 pg/mL, < 0.001), IL-6 (-11.9 pg/mL, < 0.001), and CK (-30 U/L, = 0.01). No adverse events were reported.
CONCLUSION
TUS is a safe, effective adjunct for reducing exercise-induced muscle soreness and fatigue in women with T2D, with benefits in glycemic control and inflammation. Larger trials with sham controls are needed.
TRIAL REGISTRATION
This trial was registered at the Iranian Registry of Clinical Trials (IRCT20211201053244N1) on June 21, 2022.
背景
运动引起的肌肉酸痛和疲劳是 2 型糖尿病（T2D）中年女性进行体育活动的重大障碍，组织愈合受损和慢性炎症会加剧这些问题。
目的
评估运动后治疗性超声（TUS）是否能有效减轻 T2D 女性运动引起的肌肉酸痛和疲劳，同时改善代谢和炎症生物标志物。
设计
随机对照试验。
方法
30 名久坐不动的 T2D 女性（年龄 41 - 49 岁，糖化血红蛋白（HbA1c）6.5% - 9.0%）被随机分为 TUS 组（n = 15）或对照组（n = 15）。两组均完成为期 8 周的有氧骑行计划（每周 3 次，每次 45 分钟，60% - 70%最大摄氧量）。TUS 组使用 Intellect Mobile 2 设备在运动后接受超声治疗（3MHz，1W/cm²，每条腿 7 分钟）。主要结局指标为疼痛（冯·科夫量表）和疲劳（博格量表），次要结局指标包括空腹血糖（FBS）、HbA1c、炎症标志物（肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6））以及肌酸激酶（CK），在基线和干预后进行评估。采用线性混合效应模型对基线疼痛差异进行校正。
结果
与对照组相比，TUS 组的疼痛（-2.2，95%置信区间：-2.8 至 -1.6，P < 0.001）和疲劳（-1.8，95%置信区间：-2.4 至 -1.2，P = 0.004）显著降低。次要结局指标也有显著改善：HbA1c（-0.5%，P = 0.03）、FBS（-19.8mg/dL，P = 0.01）、TNF-α（-24.9pg/mL，P < 0.001）、IL-6（-11.9pg/mL，P < 0.001）和 CK（-30U/L，P = 0.01）。未报告不良事件。
结论
TUS 是一种安全、有效的辅助手段，可减轻 T2D 女性运动引起的肌肉酸痛和疲劳，对血糖控制和炎症有益。需要进行更大规模的有假对照的试验。
试验注册
该试验于 2022 年 6 月 21 日在伊朗临床试验注册中心（IRCT20211201053244N1）注册。
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