北印度人群中人类白细胞抗原等位基因多态性的患病率

Prevalence of Human Leukocyte Antigen Alleles Polymorphism in North Indian Population.

作者信息

Yadav Brijesh, Prasad Narayan, Kushwaha Ravi Shanker, Patel Manas, Bhadauria Dharmendra Singh, Kaul Anupma

机构信息

Department of Nephrology and Kidney Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

出版信息

Indian J Nephrol. 2025 Jul-Aug;35(4):536-541. doi: 10.25259/ijn_516_23. Epub 2024 Sep 18.

DOI:10.25259/ijn_516_23

PMID:40896631

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12392222/

Abstract

BACKGROUND

Human leukocyte antigens (HLA) are highly polymorphic glycoproteins required for immune response and recognizing self or non-self. Knowing the HLA diversity in a population may be helpful in the selection of organ allocation for transplantation. We aimed to retrospectively analyze the prevalence of HLA, A, B, C, DRB1, and DQA1 alleles frequency in the north Indian population.

MATERIALS AND METHODS

HLA antigen allele data were retrospectively analyzed from a transplant cohort of 2259 subjects. HLA-A, B, and DRB1 frequency were determined in 2259, HLA-C in 759 and DQA1 in 751 subjects.

RESULTS

The most abundant HLA-A antigen alleles were HLA-A01(25.41%), HLA-A02 (24.83%), HLA-A11 (17.53%), HLA-A24 (10.27%), HLA-A03 (9.07%). HLA-B antigen alleles were HLA-B35 (20.54%), HLA-B15 (15.36%), HLA-B40 (13.59%), HLA-B07 (10.14%), HLA-B44 (7.79). HLA-C antigen alleles were HLA-C07 (28.06%), HLA-C04 (20.42%), HLA-C03 (15.55%), HLA-C06 (13.04%), HLA-C12 (5.27%). HLA-DRB1 alleles were HLA-DRB107 (21.60%), HLA-DRB104 (19.74%), HLA-DRB110 (13.15%), HLA-DRB103 (10.80%), HLA-DRB111 (8.63%). HLA-DQA1 antigen alleles were HLA-DQA103 (35.42%), HLA-DQA102 (30.89%), HLA-DQA105 (21.84%), HLA-DQA1 06 (10.12%), HLA-DQA1*04 (1.07%).

CONCLUSION

The most frequent HLA alleles were HLA-A01(25.41%), HLA-B35 (20.54%), HLA-C07 (28.06%), HLA-DRB107(21.60%), HLA-DQA1*03(35.42%) in north Indian population.

摘要

背景

人类白细胞抗原（HLA）是免疫反应以及识别自身或非自身所必需的高度多态性糖蛋白。了解某一人群中的HLA多样性可能有助于移植器官分配的选择。我们旨在回顾性分析印度北部人群中HLA-A、B、C、DRB1和DQA1等位基因频率的流行情况。

材料与方法

对2259名受试者的移植队列中的HLA抗原等位基因数据进行回顾性分析。测定了2259名受试者的HLA-A、B和DRB1频率，759名受试者的HLA-C频率以及751名受试者的DQA1频率。

结果

最常见的HLA-A抗原等位基因是HLA-A01（25.41%）、HLA-A02（24.83%）、HLA-A11（17.53%）、HLA-A24（10.27%）、HLA-A03（9.07%）。HLA-B抗原等位基因是HLA-B35（20.54%）、HLA-B15（15.36%）、HLA-B40（13.59%）、HLA-B07（10.14%）、HLA-B44（7.79%）。HLA-C抗原等位基因是HLA-C07（28.06%）、HLA-C04（20.42%）、HLA-C03（15.55%）、HLA-C06（13.04%）、HLA-C12（5.27%）。HLA-DRB1等位基因是HLA-DRB107（21.60%）、HLA-DRB104（19.74%）、HLA-DRB110（13.15%）、HLA-DRB103（10.80%）、HLA-DRB111（8.63%）。HLA-DQA1抗原等位基因是HLA-DQA103（35.42%）、HLA-DQA102（30.89%）、HLA-DQA105（21.84%）、HLA-DQA106（10.12%）、HLA-DQA1*04（1.07%）。