Han Y, Lawson W B, Dodds W J, Lawrence C E
Thromb Haemost. 1985 Oct 30;54(3):704-8.
A robust two-way analysis of variance technique was applied to determine simultaneously the effects of method and thromboplastin on prothrombin time. A new approach to outlier detection for two-way analysis of variance was used. Focusing on the underlying error structure improved the uniformity of the grading procedure in the hematology proficiency testing program of the New York State Department of Health. The logarithm-transformed scale produced constancy of error variance and resulted in uniformity of the acceptable spread of data. The common variance was lower than that obtained by previous methods and allowed for a narrower acceptable range of reported prothrombin times by reducing the inflated standard deviation, thus improving the efficiency of the grading procedure. For proficiency testing, no advantage was found in the use of either a common thromboplastin or freeze-dried, coumadinized patient plasmas rather than artificially depleted commercial plasmas, except for special purposes.
应用一种稳健的双向方差分析技术来同时确定方法和凝血活酶对凝血酶原时间的影响。采用了一种用于双向方差分析的异常值检测新方法。关注潜在的误差结构提高了纽约州卫生部血液学能力验证计划中分级程序的一致性。对数变换尺度产生了误差方差的稳定性，并导致数据可接受范围的一致性。共同方差低于以前方法获得的方差，通过减少夸大的标准差允许报告的凝血酶原时间有更窄的可接受范围，从而提高了分级程序的效率。对于能力验证，除特殊目的外，使用共同凝血活酶或冻干的、香豆素化的患者血浆而非人工耗尽的商业血浆没有发现优势。
