Evatt B L, Brogan D, Triplett D, Koepke J, Waters G
Clin Lab Haematol. 1981;3(4):331-42.
Prothrombin time was measured in three different plasma samples by 2580 laboratories in the 1977 CAP Proficiency Testing Program. Analysis of variance was used to show that instrument, as well as thromboplastin, has a significant effect upon observed prothrombin time. In addition, the instrument and thromboplastin effects were estimated, and all were shown to be linearly related to the prothrombin time of the plasma sample. This linear relationship was used to develop a formula for adjusting/correcting an observed prothrombin time for both the thromboplastin and instrument effect. This adjustment/correction method seems promising on the basis of its use in four different sets of data.
在1977年的美国病理学家协会能力验证计划中，2580个实验室对三种不同的血浆样本进行了凝血酶原时间测量。方差分析表明，仪器以及凝血活酶对所观察到的凝血酶原时间有显著影响。此外，对仪器和凝血活酶的影响进行了估计，结果显示所有这些影响均与血浆样本的凝血酶原时间呈线性关系。利用这种线性关系推导出了一个公式，用于针对凝血活酶和仪器的影响对所观察到的凝血酶原时间进行调整/校正。基于该方法在四组不同数据中的应用，这种调整/校正方法似乎很有前景。
