van den Besselaar A M, Evatt B L, Brogan D R, Triplett D A
Am J Clin Pathol. 1984 Dec;82(6):688-99. doi: 10.1093/ajcp/82.6.688.
Prothrombin times accumulated from ten different proficiency testing surveys were analyzed in terms of a linear additive model described by Evatt et al (Clin Lab Haemat 1981; 3:331-342). Different types of lyophilized plasma samples were used, i.e., plasmas artificially depleted of coagulation factors by adsorption to aluminum hydroxide, and pooled plasmas of patients receiving coumarin drugs. For each plasma sample, both instruments and thromboplastins had a highly significant effect on the prothrombin time. For most instruments and thromboplastins, a good correlation was found between instrument effect or thromboplastin effect and the mean prothrombin time if various artificially depleted plasma samples from a single manufacturer were used. Artificially depleted plasmas from a second manufacturer gave different relationships between estimated effects and mean prothrombin time. Relationships based on lyophilized pooled patient plasmas were different from those of artificially depleted plasmas from either manufacturer. The potential use of the additive linear model for standardization of the prothrombin time in monitoring oral anticoagulant therapy is discussed. Additional studies are required to establish the suitability of this model to define a universal scale for prothrombin times of fresh plasma samples of anticoagulated patients. If suitable, the model can be linked to the International Normalized Ratio proposed by the World Health Organization.
根据伊瓦特等人（《临床实验室血液学》，1981年；3:331 - 342）描述的线性加性模型，分析了来自十次不同能力验证调查积累的凝血酶原时间。使用了不同类型的冻干血浆样本，即通过吸附到氢氧化铝上人工去除凝血因子的血浆，以及接受香豆素类药物治疗患者的混合血浆。对于每个血浆样本，仪器和凝血活酶对凝血酶原时间均有高度显著影响。对于大多数仪器和凝血活酶，如果使用来自单一制造商的各种人工去除血浆样本，在仪器效应或凝血活酶效应与平均凝血酶原时间之间发现了良好的相关性。来自第二家制造商的人工去除血浆在估计效应与平均凝血酶原时间之间呈现出不同的关系。基于冻干患者混合血浆的关系与来自任何一家制造商的人工去除血浆的关系不同。讨论了加性线性模型在监测口服抗凝治疗中凝血酶原时间标准化方面的潜在用途。需要进行更多研究以确定该模型是否适合为抗凝患者新鲜血浆样本的凝血酶原时间定义一个通用尺度。如果合适，该模型可与世界卫生组织提出的国际标准化比值相关联。
