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Disarming COX-1 to disrupt Alzheimer's inflammatory trajectory: preclinical insights and translational promise.

作者信息

Loffredo Gilda, D'Amelio Marcello

机构信息

Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.

Wyss Center for Bio and Neuro Engineering, Geneva, Switzerland.

出版信息

Transl Neurodegener. 2025 Sep 2;14(1):46. doi: 10.1186/s40035-025-00509-1.

DOI:10.1186/s40035-025-00509-1
PMID:40898366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12403875/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91c5/12403875/13f8aeab2f1b/40035_2025_509_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91c5/12403875/13f8aeab2f1b/40035_2025_509_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91c5/12403875/13f8aeab2f1b/40035_2025_509_Fig1_HTML.jpg

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本文引用的文献

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Cyclooxygenase-1 deletion in 5 × FAD mice protects against microglia-induced neuroinflammation and mitigates cognitive impairment.5×FAD小鼠中环氧合酶-1缺失可预防小胶质细胞诱导的神经炎症并减轻认知障碍。
Transl Neurodegener. 2025 Aug 22;14(1):43. doi: 10.1186/s40035-025-00501-9.
2
Neuroinflammation in Alzheimer disease.阿尔茨海默病中的神经炎症
Nat Rev Immunol. 2025 May;25(5):321-352. doi: 10.1038/s41577-024-01104-7. Epub 2024 Dec 9.
3
2024 Alzheimer's disease facts and figures.2024 年阿尔茨海默病事实和数据。
Alzheimers Dement. 2024 May;20(5):3708-3821. doi: 10.1002/alz.13809. Epub 2024 Apr 30.
4
The role of dopamine in NLRP3 inflammasome inhibition: Implications for neurodegenerative diseases.多巴胺在 NLRP3 炎性小体抑制中的作用：对神经退行性疾病的影响。
Ageing Res Rev. 2023 Jun;87:101907. doi: 10.1016/j.arr.2023.101907. Epub 2023 Mar 8.
5
Microglia as a cellular target of diclofenac therapy in Alzheimer's disease.小胶质细胞作为双氯芬酸治疗阿尔茨海默病的细胞靶点。
Ther Adv Neurol Disord. 2023 Feb 27;16:17562864231156674. doi: 10.1177/17562864231156674. eCollection 2023.
6
Dopamine signaling modulates microglial NLRP3 inflammasome activation: implications for Parkinson's disease.多巴胺信号调节小胶质细胞 NLRP3 炎症小体的激活：对帕金森病的影响。
J Neuroinflammation. 2022 Feb 16;19(1):50. doi: 10.1186/s12974-022-02410-4.
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In vivo human molecular neuroimaging of dopaminergic vulnerability along the Alzheimer's disease phases.在阿尔茨海默病各阶段对多巴胺能易损性进行的活体人类分子神经影像学研究。
Alzheimers Res Ther. 2021 Nov 12;13(1):187. doi: 10.1186/s13195-021-00925-1.
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Is cyclooxygenase-1 involved in neuroinflammation?环氧化酶-1 是否与神经炎症有关？
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