Bayrak Gökhan, Aslan Ummuhan Baş
Physiotherapy and Rehabilitation Department of the Faculty of Health Sciences, Muş Alparslan University, Muş, Türkiye.
Faculty of Physiotherapy and Rehabilitation, Pamukkale University, Denizli, Türkiye.
Medicine (Baltimore). 2025 Aug 29;104(35):e44016. doi: 10.1097/MD.0000000000044016.
Aggressive osteoblastoma (AO) is an extremely rare cancer that mainly affects the spine and long bones and is less frequent in craniofacial bones. Cases involving the skull are even rarer, and the low incidence rates limit our understanding of the distribution and treatment strategies of AO. The aim of this study was to explore the clinical features, imaging findings, pathological characteristics, diagnoses, treatment, and prognosis of AO involving the skull.
A 13-year-old male was admitted to the hospital with a painless mass on the forehead that had gradually enlarged over the past year.
Magnetic resonance imaging of the head revealed an abnormal signal corresponding to a region with an unclear boundary measuring 2.32 cm × 2.23 cm × 2.64 cm on the left side of the frontal bone.
The entire mass was removed, and postoperative pathological examination led to a diagnosis of epithelioid osteoblastoma.
The patient was periodically followed up for a year, and no tumor recurrence or metastasis was observed.
AO can be diagnosed on the basis of histological examination, immunohistochemical analysis, and imaging. Gross tumor resection and regular re-examination are suitable treatment options.
Level I - randomized-controlled study.
侵袭性骨母细胞瘤（AO）是一种极其罕见的癌症，主要影响脊柱和长骨，在颅面骨中较少见。涉及颅骨的病例更为罕见，低发病率限制了我们对AO的分布和治疗策略的了解。本研究的目的是探讨累及颅骨的AO的临床特征、影像学表现、病理特征、诊断、治疗及预后。
一名13岁男性因前额无痛性肿块入院，该肿块在过去一年中逐渐增大。
头部磁共振成像显示额骨左侧有一个边界不清的区域，对应异常信号，大小为2.32 cm×2.23 cm×2.64 cm。
完整切除整个肿块，术后病理检查诊断为上皮样骨母细胞瘤。
对患者进行为期一年的定期随访，未观察到肿瘤复发或转移。
AO可根据组织学检查、免疫组化分析和影像学进行诊断。肿瘤全切和定期复查是合适的治疗选择。
一级——随机对照研究。
