Anyiam Arinze Favour, Muhibi Musa Abidemi, Arinze-Anyiam Onyinye Cecilia, Obeagu Emmanuel Ifeanyi
Department of Medical Laboratory Science, Faculty of Applied Health Sciences, Edo State University, Uzairue, Edo State, Nigeria.
Department of Medical Laboratory Science, School of Basic Medical and Health Sciences, Igbinedion University, Okada, Edo State, Nigeria.
Ann Med Surg (Lond). 2025 Jun 21;87(9):5631-5636. doi: 10.1097/MS9.0000000000003514. eCollection 2025 Sep.
has been a cornerstone of traditional medicine in Africa, renowned for its hepatoprotective, antiviral, and antidiabetic properties. However, its therapeutic applications in modern medicine are limited by poor bioavailability due to challenges such as low solubility, rapid metabolism, and instability of its bioactive compounds. Addressing these limitations is essential for optimizing its pharmacological potential and enabling its broader integration into evidence-based healthcare systems. This review highlights various strategies to enhance the bioavailability of , including nanotechnology, phytosome technology, biopiperine supplementation, fermentation, and sustained-release formulations. These approaches not only improve solubility and absorption but also stabilize the herb's phytochemicals, ensuring better therapeutic outcomes. Moreover, the review explores how bioavailability enhancement can transform into a standardized therapeutic agent, bridging the gap between traditional and modern medicine. Enhancing the bioavailability of has profound implications for healthcare in Africa. Improved formulations can amplify its therapeutic efficacy in traditional practices, while enabling its adoption in modern pharmacology through clinical validation and pharmaceutical-grade products. By addressing cost, accessibility, and regulatory challenges, these advancements can ensure that continues to be a vital, sustainable resource in addressing pressing health issues across the continent.
一直是非洲传统医学的基石，以其保肝、抗病毒和抗糖尿病特性而闻名。然而，由于其生物活性化合物存在低溶解度、快速代谢和不稳定等挑战，导致生物利用度差，限制了其在现代医学中的治疗应用。解决这些限制对于优化其药理潜力并使其更广泛地融入循证医疗体系至关重要。本综述强调了提高其生物利用度的各种策略，包括纳米技术、磷脂体技术、补充生物胡椒碱、发酵和缓释制剂。这些方法不仅提高了溶解度和吸收率，还稳定了草药的植物化学物质，确保了更好的治疗效果。此外，该综述探讨了生物利用度的提高如何能将其转变为一种标准化的治疗药物，弥合传统医学与现代医学之间的差距。提高其生物利用度对非洲的医疗保健具有深远意义。改进的制剂可以在传统实践中增强其治疗效果，同时通过临床验证和医药级产品使其能够被现代药理学采用。通过解决成本、可及性和监管挑战，这些进展可以确保它继续成为解决非洲大陆紧迫健康问题的重要、可持续资源。
