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槲皮素:主要药理活性及其在临床医学中的潜在应用。

Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine.

机构信息

Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China.

出版信息

Oxid Med Cell Longev. 2020 Dec 30;2020:8825387. doi: 10.1155/2020/8825387. eCollection 2020.

DOI:10.1155/2020/8825387
PMID:33488935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7790550/
Abstract

Quercetin is a flavonoid compound widely present in plants and exhibits a variety of biological activities. Research on quercetin has shown its potential for medical application. In this research, we elucidate its antioxidant mechanism and the broad-spectrum antibacterial and antiparasite properties; summarise its potential application in antioncology and cardiovascular protection and anti-immunosuppression treatment; and demonstrate its ability to alleviate the toxicity of mycotoxins. This research is expected to offer some insights and inspirations for the further study of quercetin, its properties, and the scientific basis for its better application in clinical practice.

摘要

槲皮素是一种广泛存在于植物中的类黄酮化合物,具有多种生物活性。对槲皮素的研究表明它具有医学应用的潜力。在这项研究中,我们阐明了其抗氧化机制以及广谱抗菌和抗寄生虫特性;总结了其在抗肿瘤、心血管保护和抗免疫抑制治疗方面的潜在应用;并证明了其缓解霉菌毒素毒性的能力。这项研究有望为进一步研究槲皮素、其性质以及更好地将其应用于临床实践提供一些见解和启示。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d02/7790550/01b7ebaac539/OMCL2020-8825387.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d02/7790550/01b7ebaac539/OMCL2020-8825387.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d02/7790550/01b7ebaac539/OMCL2020-8825387.001.jpg

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Demonstration of bactericidal and synergistic activity of quercetin with meropenem among pathogenic carbapenem resistant Escherichia coli and Klebsiella pneumoniae.
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