Jokari Ramin, Mahyari Zahra, Moulodi Mohammad Javad, Fatemi Ghiri Seyyed Mohammad, Tajalizadeh Hadi, Loloee Jahromi Ali, Nakhostin Alireza, Abdollahifard Gholamreza, Parsaei Hossein
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Basamad Azma Novin Pars Co. Ltd, Innovation and Acceleration Center, Shiraz University of Medical Sciences, Shiraz, Iran.
J Biomed Phys Eng. 2025 Aug 1;15(4):385-392. doi: 10.31661/jbpe.v0i0.2305-1618. eCollection 2025 Aug.
Diabetes is a global concern, with an estimated 2 million individuals expected to be affected by the condition by 2024. Non-invasive glucose monitoring devices can greatly enhance patient care and management.
This study aimed to develop an instrument capable of non-invasively measuring blood glucose levels using an infrared transmitter and receiver, with data processing performed by a dedicated processor.
This analytical study develops a glucometer that incorporates a power supply, a light source, a light detector, a sampler, and signal processing components to enable non-invasive glucose measurements. The instrument was calibrated using sugar solution samples with known glucose concentrations. It was then tested using serum samples from diabetic patients with accuracy, which was evaluated using Clarke's grid analysis.
Testing of the designed glucometer revealed that 83% of the serum samples fell within zone A of Clarke's grid analysis, indicating high accuracy. The remaining 17% of samples were classified in zone B, with no samples falling in zones C, D, or E.
The developed glucometer demonstrated higher accuracy in measuring glucose concentrations above 200 mg/dl. Despite the use of serum samples in this experiment, 83% of the results were located in zone A leads to the capability of non-invasively measuring blood glucose levels. Further studies are required to validate the device's accuracy in a larger population and assess its utility in clinical practice.
糖尿病是一个全球性问题，预计到2024年将有200万人受该疾病影响。非侵入式血糖监测设备可极大地改善患者护理与管理。
本研究旨在开发一种仪器，该仪器能够使用红外发射器和接收器非侵入性地测量血糖水平，并由专用处理器进行数据处理。
本分析性研究开发了一种血糖仪，其包含电源、光源、光探测器、采样器和信号处理组件，以实现非侵入性血糖测量。该仪器使用已知葡萄糖浓度的糖溶液样本进行校准。然后使用糖尿病患者的血清样本进行测试，并通过克拉克网格分析评估其准确性。
对设计的血糖仪进行测试发现，83%的血清样本落在克拉克网格分析的A区，表明准确性高。其余17%的样本被归类在B区，没有样本落在C、D或E区。
所开发的血糖仪在测量高于200mg/dl的葡萄糖浓度时显示出更高的准确性。尽管本实验中使用了血清样本，但83%的结果位于A区，这表明该仪器具有非侵入性测量血糖水平的能力。需要进一步研究以在更大规模人群中验证该设备的准确性，并评估其在临床实践中的效用。
