Alibaud R, Bontoux J, Rambaud A, Lautier J, Chanal J L
Xenobiotica. 1985 Dec;15(12):1103-10. doi: 10.3109/00498258509049104.
The acute toxicities of dimethylnitrosamine and diethylnitrosamine have been evaluated in adult male crayfish Austropotamobius pallipes; LD50 values are 2250 mg/kg and 230 mg/kg, respectively. Toxicokinetic studies of 14C-dimethylnitrosamine and 14C-diethylnitrosamine in crayfish, administered by i.v. injection, show high concentrations of 14C in abdominal muscle and hepatopancreas. Excretion is greater with dimethylnitrosamine, and retention in the tissues, especially the hepatopancreas, is greater with diethylnitrosamine. Metabolites identified in excreta include monomethylnitrosamine from dimethylnitrosamine, and hydroxyethyl-ethyl-, bishydroxyethyl- and carboxyethyl-ethylnitrosamine from diethylnitrosamine.
已对成年雄性小龙虾Austropotamobius pallipes评估了二甲基亚硝胺和二乙基亚硝胺的急性毒性；半数致死量值分别为2250毫克/千克和230毫克/千克。通过静脉注射给予小龙虾14C-二甲基亚硝胺和14C-二乙基亚硝胺的毒代动力学研究表明，腹部肌肉和肝胰腺中14C的浓度很高。二甲基亚硝胺的排泄量更大，而二乙基亚硝胺在组织尤其是肝胰腺中的滞留量更大。排泄物中鉴定出的代谢产物包括二甲基亚硝胺产生的单甲基亚硝胺，以及二乙基亚硝胺产生的羟乙基-乙基、双羟乙基和羧乙基-乙基亚硝胺。
